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Naoko Aizawa, Hiroshi Kunikata, Satoru Tsuda, Yukihiro Shiga, Yukiko Maiya, Naoki Kiyota, Kazuko Omodaka, Yu Yokoyama, Morin Ryu, Toru Nakazawa; Preperimetric glaucoma pathophysiological study part1:Twelve-month results of topical prostaglandin analogues. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2750.
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© ARVO (1962-2015); The Authors (2016-present)
A treatment plan has not been established in preperimetric glaucoma (PPG). We are investigating prospectively the response to topical prostaglandin analogues on microcirculation in eyes with PPG. Here, we report 12-month results on intraocular pressure (IOP) and optic nerve head (ONH) microcirculation in this study.
This study is prospective observational study. We collected 136 eyes with PPG of 136 patients (53.8 ± 14.3 years) treated with tafluprost. The IOP, mean blur rate (MBR) in the ONH, mean deviation (MD) and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) were measured with Goldmann applanation tonometry, laser speckle flowgraphy (LSFG-NAVI), standard automated perimetry and optical coherence tomography, respectively, before and from 4 and 12 months after tafluprost administration.
Before administration, IOP, MBR, MD and cpRNFLT were 16.5 ± 2.5mmHg, 23.98 ± 4.68, -0.59 ± 1.34 dB and 79.6 ± 8.3 um, respectively. IOP decreased significantly 4 month and 12 month after tafluprost administration (14.6 ± 2.4mmHg, P＜0.001 and 14.6 ± 2.6mmHg, P＜0.001, respectively). MBR increased significantly 4 month and 12 month after tafluprost administration (1.98 ± 7.80%, P=0.007 and 2.64 ± 10.43%, P=0.042, respectively).
Topical treatment with tafluprost decreases IOP and increases optic nerve blood flow with long-term stability in patients with PPG.
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