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Ji Eun E Lee, Boo Sup Oum, Jae Jung Lee, Min Kyu Shin, Inyoung Chung, Joo Eun Lee, Hyun Woong Kim, Sang-Joon Lee, Sung Who Park, Ik Soo Byon; Topographic Relationship between Choroidal Watershed Zone and Idiopathic Submacular Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2775.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between idiopathic choroidal neovascularization (CNV) and choroidal watershed zones (CWZ) using indocyanine green angiography (ICGA).
This study was a retrospective case series from five centers. The medical records and ICGA of 44 patients (44 eyes) who were diagnosed with idiopathic CNV were reviewed. A CWZ was defined as hypofluorescence that disappeared during the early phase of ICGA. A CWZ was classified and compared to control group of 29 eyes. The topographic relationship between the CWZ and CNV was evaluated. Visual acuity and recurrence were analyzed according to the CWZ classification.
The CNV lesion was subfoveal in 16 eyes, juxtafoveal in 12 eyes, and extrafoveal in 16 eyes. A stellate CWZ was the most common type (23 eyes; 52.3%), and followed by a vertical CWZ (19 eyes; 43.2%). The CWZ classification did not differ from control group. A CWZ involved the fovea more frequently in idiopathic CNV patients (37 eyes, 88.6%) than control group (10 eyes, 34.5%, P<0.001). The topographical relationship between the CWZ and CNV was determined in 42 eyes (95.5%), as the CNV was located within the CWZ in 39 eyes and at the margin in 3 eyes. Extrafoveal CNV was within the CWZ in all eyes. At 6 months, visual acuity was significantly worse in patients with a subfoveal CNV (P=0.028) and a stellate CWZ (P=0.039).
A CWZ was related to idiopathic CNV topographically and the functional outcomes. Our results suggest that a CWZ is a predisposition for the development of CNV in young patients.
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