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Brian Evan Goldhagen, John Edward Legarreta, Andrew Dominic Legarreta, Emeline Radhika Ramenaden, Karen Schaal, Paul F Stetson, Ming Cai, Michal Laron, Giovanni Gregori, Philip J Rosenfeld; Widefield En face Swept Source OCT Imaging of Geographic Atrophy, Retinal Pigment Epithelial Detachments, and Macular Hemorrhages. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2782.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate the benefits of 12X12 mm widefield en face swept source optical coherence tomography (SS-OCT) imaging of eyes with geographic atrophy (GA), retinal pigment epithelial detachments (PEDs), and/or macular hemorrhages secondary to age-related macular degeneration (AMD).
Patients with the diagnosis of dry AMD were imaged using a prototype Zeiss 100 kHz SS-OCT instrument (Carl Zeiss Meditec Inc., Dublin, CA) with a central wavelength of 1050 nm. SS-OCT volume scans were obtained using a 12X12 mm raster scan pattern centered on the fovea. In the 12 mm transverse scanning direction, a single Bscan was comprised of 512 A-scans with each 3 mm deep A-scan separated by 23.4 μm and comprised of 1500 pixels. In the 12 mm vertical scanning direction, a total of 512 B-scans positions were performed, each separated by 23.4 μm. Different en face slabs were evaluated ranging from 55 μm above the retinal pigment epithelium (RPE) to 528 μm below the RPE. These widefield en face images were then compared with the corresponding B-scans, as well as color, autofluorescence, and infrared-reflectance images.
A total of 258 patients were scanned with the prototype SS-OCT instrument and also underwent multimodal fundus imaging. A total of 100 patients (163 eyes) were diagnosed with GA, 74 patients (103 eyes) were diagnosed with PEDs and 26 patients (28 eyes) were diagnosed with macular hemorrhages. Regardless of size, the PEDs and hemorrhages could be easily identified and characterized from the en face images and B-scans, and the PEDS could be assessed volumetrically. The GA from all of these eyes could be easily identified using a sub-RPE slab with a thickness of 464 μm.
Widefield 12X12 mm en face slab imaging with SS-OCT can reliably detect and characterize PEDs, macular hemorrhages, and GA and could replace color, infrared, and autofluorescence imaging.
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