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Ryan P McNabb, Dilraj Singh Grewal, Stefanie Schuman, Prithvi Mruthyunjaya, Joseph A Izatt, Anthony N Kuo; Ultra wide-field swept-source optical coherence tomography for peripheral eye disease. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2804. doi: https://doi.org/.
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In order to image peripheral retinal pathologies and the posterior pole in a single volume acquisition, our purpose was to develop a high resolution, ultra-wide field of view optical coherence tomography (UWFOCT) system.
We developed a custom UWFOCT sample arm utilizing clinical wide-field, indirect ophthalmic lenses. We based our OCT engine on a swept laser (λ0 = 1050±50nm, Axsun Tech., Inc.) with an A-scan rate of 100 kHz. Volumes up to 720 x 720 (A x B-scans) were acquired in 5.2 s. B-scans averaged up to 100 frames (688 depth x 2500 A-scans) were acquired in 2.5 s. Subjects with peripheral retinal pathologies (choroidal tumors [nevi, melanomas, sclerochoroidal calcification], retinitis pigmentosa, and degenerative retinoschisis) were drawn from the retina clinics of the Duke Eye Center. We obtained informed consent from subjects prior to imaging. We imaged subjects after their standard of care clinical exam which included dilation, scanning laser ophthalmoscopy (SLO: Optos), clinical OCT (Spectralis), and/or fundus photography. We acquired volumes and averaged B-scans in the eye with peripheral retinal pathology.
A total of 18 subjects were imaged (14 tumors, 2 RP, 2 retinoschisis). Representative UWFOCT images are shown in the Figures. In all subjects, single volume acquisitions contained both the posterior pole and peripheral pathologies. More anterior retinoschisis lesions were not consistently imaged in standard primary fixation.
We have developed an ultra-wide FOV OCT system capable of high resolution imaging of both the macula and retinal periphery. This system has promise for rapidly screening and imaging both posterior and peripheral retinal pathologies within a single volumetric acquisition.
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