June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Ultra wide-field swept-source optical coherence tomography for peripheral eye disease
Author Affiliations & Notes
  • Ryan P McNabb
    Ophthalmology, Duke University Medical Center, Durham, NC
  • Dilraj Singh Grewal
    Ophthalmology, Duke University Medical Center, Durham, NC
  • Stefanie Schuman
    Ophthalmology, Duke University Medical Center, Durham, NC
  • Prithvi Mruthyunjaya
    Ophthalmology, Duke University Medical Center, Durham, NC
  • Joseph A Izatt
    Ophthalmology, Duke University Medical Center, Durham, NC
    Biomedical Engineering, Duke University, Durham, NC
  • Anthony N Kuo
    Ophthalmology, Duke University Medical Center, Durham, NC
  • Footnotes
    Commercial Relationships Ryan McNabb, Alcon (F); Dilraj Grewal, None; Stefanie Schuman, None; Prithvi Mruthyunjaya, None; Joseph Izatt, Bioptigen (C), Bioptigen (I), Bioptigen (P); Anthony Kuo, Alcon (F), Bioptigen (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2804. doi:https://doi.org/
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    • Get Citation

      Ryan P McNabb, Dilraj Singh Grewal, Stefanie Schuman, Prithvi Mruthyunjaya, Joseph A Izatt, Anthony N Kuo; Ultra wide-field swept-source optical coherence tomography for peripheral eye disease. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2804. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

In order to image peripheral retinal pathologies and the posterior pole in a single volume acquisition, our purpose was to develop a high resolution, ultra-wide field of view optical coherence tomography (UWFOCT) system.

 
Methods
 

We developed a custom UWFOCT sample arm utilizing clinical wide-field, indirect ophthalmic lenses. We based our OCT engine on a swept laser (λ0 = 1050±50nm, Axsun Tech., Inc.) with an A-scan rate of 100 kHz. Volumes up to 720 x 720 (A x B-scans) were acquired in 5.2 s. B-scans averaged up to 100 frames (688 depth x 2500 A-scans) were acquired in 2.5 s. Subjects with peripheral retinal pathologies (choroidal tumors [nevi, melanomas, sclerochoroidal calcification], retinitis pigmentosa, and degenerative retinoschisis) were drawn from the retina clinics of the Duke Eye Center. We obtained informed consent from subjects prior to imaging. We imaged subjects after their standard of care clinical exam which included dilation, scanning laser ophthalmoscopy (SLO: Optos), clinical OCT (Spectralis), and/or fundus photography. We acquired volumes and averaged B-scans in the eye with peripheral retinal pathology.

 
Results
 

A total of 18 subjects were imaged (14 tumors, 2 RP, 2 retinoschisis). Representative UWFOCT images are shown in the Figures. In all subjects, single volume acquisitions contained both the posterior pole and peripheral pathologies. More anterior retinoschisis lesions were not consistently imaged in standard primary fixation.

 
Conclusions
 

We have developed an ultra-wide FOV OCT system capable of high resolution imaging of both the macula and retinal periphery. This system has promise for rapidly screening and imaging both posterior and peripheral retinal pathologies within a single volumetric acquisition.  

 
Representative data from subject with a peripheral choroidal malignant melanoma (CMM: white arrows), cystoid macular edema and epiretinal membrane, and glaucomatous ONH cupping. A) SLO (lines approx. C and D) B) clinical OCT foveal B-scan C) UWFOCT showing fovea, ONH and posterior periphery D) UWFOCT arbitrary B-scan showing fovea and CMM.
 
Representative data from subject with a peripheral choroidal malignant melanoma (CMM: white arrows), cystoid macular edema and epiretinal membrane, and glaucomatous ONH cupping. A) SLO (lines approx. C and D) B) clinical OCT foveal B-scan C) UWFOCT showing fovea, ONH and posterior periphery D) UWFOCT arbitrary B-scan showing fovea and CMM.
 
 
Representative data from subject with retinitis pigmentosa and a macular lamellar hole. A) UWFOCT en face projection with green arrow locating: B) UWFOCT arbitrary B-scan showing ONH, fovea with LH (arrow), and periphery with retinal and choroidal thinning as well as characteristic RP spicules.
 
Representative data from subject with retinitis pigmentosa and a macular lamellar hole. A) UWFOCT en face projection with green arrow locating: B) UWFOCT arbitrary B-scan showing ONH, fovea with LH (arrow), and periphery with retinal and choroidal thinning as well as characteristic RP spicules.

 
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