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Monica Jong, Pauline Xu, Ravi Chandra Bakaraju, Xiang Chen, Padmaja Sankaridurg, Martin Ma, Stephanie Song, Wayne Li, Serge Resnikoff, Brien A Holden; A dose-response relationship between duration of daily lens wear and reduction in rate of axial elongation. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2941.
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To determine if there is a dose-response relationship between duration of lens wear (hours/day) and rate of increase in axial length (AL) with myopia control lenses.
Fifty two children aged between 8 to 13 years (spherical refractive error between -0.75 D to -5.00 D, cylinder ≤ -1.00 D) with no previous myopia treatment and no systemic or ocular disease were recruited into a prospective, double-masked, randomized clinical trial at BHVI China (Jan 2014). Participants were fitted with either novel, daily disposable extended depth of focus (EDOF) contact lenses (EDOF1 or EDOF2) or single vision (SV) contact lenses. All 3 groups (EDOF1, n = 15; EDOF2, n = 21; SV, n= 16) were matched for age, gender, parental myopia, refractive error and axial length at baseline. Axial length (AL) was measured at baseline and 6 months. Duration of daily lens wear was surveyed at 6 months. Linear regression was used to analyse for significance of the dose (lens wear time)-response relationships for each lens type.
The EDOF1 and EDOF2 contact lenses showed strong negative linear relationships between the change in AL and average duration of wear (EDOF1: ΔAL = 0.235-0.014x hours/day, r = 0.74; EDOF2: ΔAL = 0.342-0.022x hours/day, r = 0.90). The SV contact lens showed a weaker negative correlation: ΔAL = 0.2878-0.0105x hours/day, r = 0.52. The AL change approached zero when wear time was 14 hours per day for EDOF1 and EDOF2.
Our 6 month results indicate a strong dose-response relationship whereby greater hours of wear per day was associated with less AL increase for both types of EDOF lenses. EDOF lenses appear to be more useful for myopia control when worn for longer hours each day.
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