June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
The Structural Changes of Myopic Eyes in Children with Retinopathy of Prematurity
Author Affiliations & Notes
  • Saira Bhatti
    Ophthalmology, Baylor College of Medicine, Houston, TX
  • Evelyn A. Paysee
    Ophthalmology, Baylor College of Medicine, Houston, TX
  • Mitchell P. Weikert
    Ophthalmology, Baylor College of Medicine, Houston, TX
  • Lingkun Kong
    Ophthalmology, Baylor College of Medicine, Houston, TX
  • Footnotes
    Commercial Relationships Saira Bhatti, None; Evelyn Paysee, None; Mitchell Weikert, None; Lingkun Kong, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2953. doi:
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      Saira Bhatti, Evelyn A. Paysee, Mitchell P. Weikert, Lingkun Kong; The Structural Changes of Myopic Eyes in Children with Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2953.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: The prevalence of myopia in premature infants is higher than in full term infants. However, the mechanisms and structural contributions to myopia in preterm infants are unclear. We conducted a case control study to test the hypothesis that the structural contribution to myopia in preterm and full term born children is different.

Methods: This was a case control study. 114 children ranging from ages 2 to 17 who had myopia ≥ -3 diopters or hyperopia ≥3 diopters in at least one eye were examined with A-scans. The following data was collected and analyzed: history of birth, refractive error, visual acuity, cornea thickness, axial length of the eye, depth of anterior chamber (ACD) and thickness of lens.

Results: Patients were tested and categorized into 3 major groups: group 1 consisting of premature infants with myopia (gestation age <32 wks., birth weight <1500g), group 2 consisting of full-term infants with myopia, and group 3 consisting of full-term infants without myopia. The refractive errors were -10.0±5.2 in group 1, -8.4±4.6 in group 2, and 2.3±2.4 in group 3. There was no difference found in corneal thickness among these groups. The axial length (AL) of myopic eyes in group 2 was longer than that of group 1 (mean AL = 24.9 ± 1.9 mm vs. 23.1 ±1.4mm), p=0.01. The ACD in premature children was more shallow than that of full term myopic eyes (2.5 ±0.5 vs. 3.2 ±0.3, p=0.01). Finally, lens thickness (LT) measurements in group 1 were thicker than those in group 2 (mean LT = 4.9 ± 1.0 vs 4.1 ± 0.3 mm, p=0.001, respectively).

Conclusions: These results suggest that increased axial length plays an important role in myopia in full-term children, while lens thickness is a major contributor for myopia in preterm-born children.


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