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Hirotaka Tanabe, Minako Kaido, Motoko Kawashima, Reiko Ishida, Kazuo Tsubota; Effect of Eye Shampoo for Obstructive Meibomian Gland Disease. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3052.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the efficacy of eyelid margin cleansing with Eye Shampoo (MediProduct©, Japan), a lid hygiene product, for obstructive obstructive meibomian gland dysfunction (MGD) patients.
Thirty-seven eyes of 37 patients (10 males, 27 females, aged 28 to 86 years [67.4±13.6 years]) diagnosed with obstructive MGD were enrolled throughout this prospective clinical study. All subjects were instructed to cleanse the eyelid margin with Eye Shampoo (MediProduct©, Japan), the lid hygiene product, at least once daily. Lid margin abnormalities, meibum properties, and tear stability were observed before and 1 month after the initiation of this study. Meibography was performed on all subjects to observe morphological characteristics of the meibomian gland before the treatment. A questionnaire relating to the severity of MGD symptoms was administered after the treatment. Scores relating to the ocular conditions, i.e., subjective symptoms improvement, corneal and conjunctival fluorescein staining scores, tear break up time (TBUT), lid margin lissamine green staining scores, mucocutaneous junction (MCJ) by fluorescein, vascular dilatation, lid margin deformation, plugging, meibum status, and meibomian gland scores by meibography were evaluated. We adhered to the tenets of Helsinki, and the ethics committee in Keio University School of Medicine approved the protocol.
There were significant improvements in TBUT, lid margin lissamine green staining scores, and meibum status (P<0.05, respectively). There were no significant improvements in corneal and conjunctival fluorescein staining scores, MCJ by fluorescein, vascular dilatation, lid margin deformation, and plugging (P≧0.05, respectively). As to subjective symptoms, there were improvements in 29 subjects, and no improvements in 8 subjects. Meibography revealed 31 subjects had normal meibomian glands (based on the aggregate scores of both upper and lower lids), and 6 subjects had meibomian gland atrophy and there were significant improvements in the subjective symptoms, TBUT, and lid margin lissamine green staining scores (P<0.05, respectively) in both groups, but meibom status (P<0.05) only in the group with normal meibomian glands. There were no obvious problems in all subjects throughout the study.
Lid margin cleansing with Eye Shampoo could be one of the effective lid hygiene options.
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