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Christopher Hudson, Faryan Tayyari, Lee-Anne Khuu, Shaun Singer, John G Flanagan, Michael H Brent, Retina Research Group; The Association of Retinal Blood Flow and Retinal Blood Oxygen Saturation in Mild-to-Moderate Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3315.
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The aim of this study was to evaluate the relationship between retinal blood flow (RBF) and retinal oxygen saturation (SO2) in mild-to-moderate non-proliferative diabetic retinopathy (NPDR) and in age-matched controls.
One eye of each of 15 healthy subjects (68.1 ± 6.0 years) and 13 subjects with mild-to-moderate NPDR (67.3 ± 10.2 years) was dilated. None of the patients with NPDR had received treatment for their retinopathic changes or had any evidence of sight-threatening characteristics. Doppler FD-OCT blood flow was measured using the prototype RTVue system (Optovue Inc., USA); six separate measurements each comprising an upper and a lower, nasal pupil scan were acquired. Non-invasive hyperspectral retinal (HR) imaging (prototype H-8.5 HR Camera, Optina, QC, Canada) was also undertaken to measure retinal blood oxygen saturation; six HR camera (including the 586 to 605nm wavelengths) measurements were acquired.
Total retinal blood flow was significantly lower in NDPR when compared to controls (42.66 ± 7.5 vs 33.73 ± 9.13; p=0.004). Mean retinal venular blood oxygen saturation was higher in NDPR than in the healthy controls (62.55 ± 5.7% vs 56.29 ± 4.7%; p=0.003). However, there was no correlation between venular retinal blood flow and venular oxygen saturation in controls (r=0.243, p=0.34) or in DR (r=0.228, p=0.45).
There was no correlation between venular retinal blood flow and retinal blood oxygen saturation. Given that there was no correlation between SO2 and RBF, the results of this study suggest that there is a need to measure both SO2 and RBF in order to calculate retinal oxygen utilization.
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