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Thomas S Hwang, Yali Jia, Simon S Gao, Andreas K Lauer, Christina J Flaxel, Steven Bailey, Phoebe Lin, David J Wilson, David Huang; Diabetic Retinopathy Features Detected with 6x6 mm OCT Angiogram Using SSADA Algorithm. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3338.
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© ARVO (1962-2015); The Authors (2016-present)
Diabetic retinopathy (DR) is a common retinal vascular disease with classic fluorescein angiography (FA) features that are useful for treatment and classification. OCT Angiography is a dye-free alternative to FA. Using a commercially available 70kHz OCT and the split-spectrum amplitude decorrelation angiography (SSADA) algorithm, 6x6 mm images can be obtained in 3.5 seconds. We evaluated the ability of this technique to detect the angiographic features catalogued by the Early Treatment of Diabetic Retinopathy Study (ETDRS).
Four patients with DR were imaged with conventional FA and OCT angiography. The images were evaluated for the ability to detect ETDRS features and other manifestations of vasculopathy.
OCT angiography detected enlargement and distortion of the foveal avascular zone, retinal capillary dropout, and pruning of arteriolar branches. Areas of capillary loss obscured by fluorescein leakage on FA were more clearly defined on OCT angiography. Some areas of focal leakage on FA that were thought to be microaneurysms were found to be small small tufts of neovascularization that extended above the inner limiting membrane.
OCT angiography does not show leakage, but can better delineate areas of capillary dropout and detect early retinal neovascularization. This new noninvasive angiography technology may be useful for routine surveillance of proliferative and ischemic changes in diabetic retinopathy.
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