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Chiara Veronese, Mariachiara Morara, Martina Melucci, Filippo Tassi, Nicole Balducci, Antonio Ciardella; Optical Coherence Tomography Angiography of Pigment Epithelial Detachment. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3352.
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© ARVO (1962-2015); The Authors (2016-present)
To noninvasively describe the spectrum of pigment epithelial detachments (PEDs) occurring mainly in age-related macular degeneration (AMD), central serous chorioretinopathy (CSC), inflammatory and iatrogenic retinal disorders with Optical Coherence Tomography Angiography (OCTA).
Observational, cross-sectional study of 34 patients (19 men and 15 women), ranged in age from 50 to 70 years (mean age 63.2 years) with drusenoid, serous, vascularized or mixed PEDs. The instrument used for the OCT images was based on the RTVue XR Avanti (Optovue Inc) and was used to obtain split- spectrum amplitude decorrelation angiography images. OCTA was performed on 3x3 mm and 6x6 mm area centered on the fovea. The 3D angiography was segmented in 4 layers: superficial and deep (to show retinal vasculature), outer retina (to identify Choroidal neovascularization) and chorio-capillary. En face maximum projection was used to obtain 2-dimensional angiograms from the 4 layers.
En face OCT angiograms of PEDs showed sizes and locations that were confirmed by fluorescein angiography (FA). OCTA of 34 eyes detected 34 PEDs : vascularized in 21 eyes (61.8%), serous in 7 eyes (20.6%), drusenoid in 4 eyes (11.8%), infiammatory in 1 eye (2.9%) and iatrogenic in 1 eye (2.9%).
OCTA provides depth-resolved information and detailed images of PEDs and may offer noninvasive differentiation between various kinds of PEDs.
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