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Alison Skalet, Yan Li, Chen D Lu, Yali Jia, ByungKun Lee, Joachim Hornegger, James G Fujimoto, David Huang; A pilot study of OCT angiography of iris melanomas. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3365. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this pilot observational clinical study was to evaluate a new, noninvasive OCT angiography technique in the imaging of iris melanomas.
The eyes of two patients who were diagnosed with iris melanoma were evaluated using a swept-source, anterior segment OCT system operating at 1050 nm wavelength and 100 kHz axial scan repetition rate. Three-dimensional OCT angiography data was acquired over 6 mm x 6 mm regions with scan depth of 5 mm in tissue by using 3 repeated B-scans at 300 raster positions, each B-scan consisting of 300 axial-scans. Horizontal and vertical raster scans were acquired and software motion correction was applied to reduce eye motion and combine the volumes. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to detect flow and construct angiograms. En face OCT angiograms were constructed by maximum flow projection.
OCT angiography detected tortuous and disorganized vascular patterns within pigmented iris melanomas in two eyes (Figure 1). In normal areas of iris outside of the region of tumor involvement, and in normal control eyes, vessels were oriented radially. The tumor vasculature appeared denser than the vessels in unaffected iris areas.
OCT angiography at 1050 nm can successfully image vasculature within pigmented iris tumors and may be a less invasive (no injection) alternative to conventional fluorescein angiography for assessing tumors vascularity and monitoring response to treatment. This is the first demonstration of OCT angiography in ocular tumors and further studies are needed.
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