June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Pupillary shapes in response to electrical stimulation of the sclera of peripheral cornea in cats and porcines
Author Affiliations & Notes
  • Yoko Hirohara
    Innovative Research Initiatives, Tokyo Institute of Technology, Yokohama, Japan
    Product Technology Sec., Eye Care Company, Topcon corp., Itabashi, Japan
  • Toshifumi Mihashi
    Innovative Research Initiatives, Tokyo Institute of Technology, Yokohama, Japan
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Tomomitsu Miyoshi
    Department of Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan
  • Suguru Miyagawa
    Fundamental Technology Sec., Topcon corp., Itabashi, Japan
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Hiroyuki Kanda
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Hajime Sawai
    Department of Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan
  • Takashi Fujikado
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Thomas Drew
    School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
  • James Stuart Wolffsohn
    School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
  • Footnotes
    Commercial Relationships Yoko Hirohara, Topcon corp. (E); Toshifumi Mihashi, Topcon corp. (F); Tomomitsu Miyoshi, None; Suguru Miyagawa, Topcon corp. (E); Hiroyuki Kanda, None; Hajime Sawai, None; Takashi Fujikado, None; Thomas Drew, None; James Wolffsohn, Johnson and Johnson (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3374. doi:https://doi.org/
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      Yoko Hirohara, Toshifumi Mihashi, Tomomitsu Miyoshi, Suguru Miyagawa, Hiroyuki Kanda, Hajime Sawai, Takashi Fujikado, Thomas Drew, James Stuart Wolffsohn; Pupillary shapes in response to electrical stimulation of the sclera of peripheral cornea in cats and porcines. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3374. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: We have reported that the changes in the pupillary shape in response to electrical stimulation of the branches of the ciliary nerves in cats. (Miyagawa et al. PLoS One, 2014). This study investigates the changes in the pupillary shapes in response to electrical stimulations of the sclera of peripheral cornea in cats and porcines.

Methods: Two enucleated eyes of two cats and three enucleated porcine eyes were studied. Trains of biphasic pulses (current, 3 mA; duration, 2 ms/phase; frequency, 40 Hz) were applied using a tungsten electrode (0.3mm diameter). The stimulation was performed at every 45 degree over the entire circular region on the sclera near the cornea. The pupillary images were recorded before and 4 s (cat) and 10 s (pig) after the stimulation and the change in the pupil diameter (Δr) was quantified. The pupillary images were obtained with a custom-built compact wavefront aberrometer (Uday et al. J Cataract Refract Surg, 2013).

Results: In a cat eye, the pupil was dilated by the electrical stimulation at six out of eight orientations (before stimulation pupil diameter r=10.10±0.49 mm, Δr=0.33±0.12 mm). The pupil dilated only toward the electrode (relative eccentricity of the pupil center to the pupil diameter change amount rdec=1.15±0.28). In the porcine eyes, the pupils were constricted by the electrical stimulations at the temporal and nasal orientations (r=10.04±0.57 mm, Δr=1.52±0.70 mm). The pupils contracted symmetrically (rdec=0.30±0.12).

Conclusions: With electrical stimulation in the sclera of the peripheral cornea, asymmetric mydriasis in cat eyes and symmetrical miosis in porcine eyes were observed. Under the assumption that the electrical stimulation stimulated both muscles that contribute to the pupil control, our hypothesis proposed here is that the pupil dilator is stronger than the pupil sphincter in cat, and pupil sphincter is stronger than pupil dilator in porcine.

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