June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Lymphoproliferative Disease of the Ocular Adnexa: Clinical Features and Subtypes
Author Affiliations & Notes
  • Nitika Arora
    Internal Medicine, University of Illinois College of medicine, Peoria, IL
  • Catherine E Cuite
    Oculoplastics, Illinois Eye Center, Peoria, IL
  • Footnotes
    Commercial Relationships Nitika Arora, None; Catherine Cuite, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3416. doi:
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      Nitika Arora, Catherine E Cuite; Lymphoproliferative Disease of the Ocular Adnexa: Clinical Features and Subtypes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3416.

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      © ARVO (1962-2015); The Authors (2016-present)

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To study the clinical features of patients presenting with ocular adnexal Lymphoproliferative disease (OALD) and their relationship with different histologic subtypes.


Data was collected retrospectively for 36 cases of OALD that were biopsied by one surgeon between 2000 and 2014. All patients were classified according to the World Health Organization modification of the Revised European American Classification. Descriptive statistics were calculated for demographics, histologic subtype of tumor, clinical stage at presentation, tumor location, presenting symptoms and tumor related mortality. Tumor location was reported as orbital, lacrimal or conjunctival. Presenting symptoms included swelling, double vision, prominent globe and tearing. Relationships between the histologic subtype and other variables were explored using two sample t test and Fisher’s exact test.


The mean age of the patients was 68.6 ± 13.4 years, and 47% were males. Fifty percent of patients had mucosa associated lymphoid tissue (MALT) followed by follicular type in 27.8%. The rest were small cell, large cell and mantle cell lymphomas. On comparing MALT and follicular type, there was no significant difference in the age of the presentation, gender, location of the tumor or clinical features of presentation (p>0.05 for all).<br /> Eighty percent of follicular lymphomas are secondary as compared to 11% in case of follicular (p=0.023). 69.4% of all the tumors were primary.


The diagnosis of orbital lymphomas is challenging because these present with few specific features. According to our study, clinical presentation, age and gender are not significant determinants of histologic subtype.<br /> Although majority of tumors were primary, follicular Lymphoma is more likely to be a secondary tumor. Follicular Lymphoma may have increased tumor-related death but our small cohort could not detect statistical significance of this finding.  


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