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Mireia Garriga Beguiristain, Miguel A Zapata, Laura Natalia Distefano, Jose Garcia-Arumi; Study of funduscopic and tomographic findings in the retina of patients with Alzheimer disease.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):369.
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© ARVO (1962-2015); The Authors (2016-present)
To derminate if mental state of patients with initial Alzheimer disease correlates with the subretinal depts (drusen-like), even in peripheral and central retina.
Transversal, descriptive and unicentric study. 60 patients, clinical diagnosticated of mild to moderate Alzheimer disease with DSM-IV criteria, where assessed with MMSE, scale of Blessed, MEC and DAD test. The ophthalmologic study was performed with wide-camp Optos for the rethinography and autofluorescence and OCT cirrus image.
Peripheral drusen where detected in 45- 50% of the right and left eyes respectively, and totally drusen in 63-60%. The thickness average of CNFL was of 84.5 µm, and in GCL was of 74%. The choroid thickness average detected was of 226 µm.<br /> This results were studied jointly with de mental tests, finding a significant statistical positive correlation between the results of the tests and the quantification of peripheral drusen (i.e. more peripheral drusen where detected in patients with worst punctuation in the test).
The presence of peripheral subretinal drusen could be associated to a worsen mental state in patients with mild to moderat Alzheimer disease.
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