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Sophia Kim, Kyung Rim Sung; Factors associated with loss of visual function in far advanced primary open angle glaucoma with lower baseline intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3697.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate risk factor associated with progressive loss of visual function in far advanced primary open angle glaucoma with lower baseline intraocular pressure(POAGLP).
Eighty nine eyes of 89POAGLP patients with baseline visual field (VF) mean deviation (MD) less than -10 decibel (dB) (average follow up period; 5.3 years) were included. Participants were categorized into two groups according to the baseline VF MD,ie, group 1 (-16 dB <), and group 2 (-16 dB >), respectively. Total participants were divided into older group (≥64 years) and younger group (<64 years) according to the median split of baseline age. Hazard ratios (HRs) for the association between potential risk factors and progression were obtained using Cox proportional hazards models in total participants as well as in each subgroup. VF progression rate was obtained by linear regression analysis of serial VF MD values and compared among three subgroups based on mean follow up IOP.
Fifty three eyes were classified as group 1 (VF MD; -13.5 ± 1.8 dB) while 36 eyes as group 2 (-21.0 ± 4.1 dB). Thirty four eyes (64.2%) in group 1and 29 eyes (80.6%) in group 2 showed progression during follow-up period. In group 1, younger age and lower baseline best-corrected visual acuity were found to be associated with progression, whereas no significant risk factor was found in group 2. In younger group, myopia and disc hemorrhage were found to be the risk factors while no risk factor was found in older group. In group with mean follow up IOP under 13.5mmHg, MD progression rate was -0.340±0.431 dB/year, while in group with IOP between 13.5mmHg and 15.2mmHg, -0.213±0.500 dB/year, in group with IOP over 15.2mmHg, -0.345±0.618 dB/year (p=0.543).
Risk factors associated with progressive loss of visual function were different according to the stages of VF or baseline age among far advanced POAGLP patients.
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