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Byung Ro Lee, Moon sang won; Evaluation of various hyper-reflective speckles according to variable stages of central serous chorioretinopathy using en-face image. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3730.
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To evaluate various types of hyper-reflective speckles in patients with acute, early chronic and late chronic central serous chorioretinopathy (CSC) using spectral domain optical coherence tomography(SD-OCT) en-face and B-scan image.
A retrospective image data analysis was conducted of patients of CSC classified three groups (acute, early chronic, late chronic) based on fluorescein angiography (FA), indocyanine green angiography (IA). We obtained B-scan and en face reconstruction image of the retinal surface using SD- OCT. The hyper-reflective speckles were categorized into three groups (intra-retinal dot, intra subretinal fluid ellipsoid, retinal pigment epithelial clump).Two authors analyzed the spatial characteristics of these hyper-reflective speckles.
There were patients with various phases of CSCR: acute (24 eyes), early chronic (13 eyes) late chronic (11 eyes). Intra-subretinalfluid(SRF) ellipsoid types were relatively more in acute CSC(87.5%). But some intra-retinal dots (62.5%) were observed in eyes with acute CSC. Intra-retinal dots were observed within the outer plexiform layer in early chrnoic CSC(23.1%), whereas ellipsoids in SRF and retina pigment epithelium crump types demonstrated 9 eyes(69.2%) and 12 eyes (92.3%) respectively. Retinal pigment epithelial clump type was major presentation in chronic CSC (90.9%).
Considering the types and distribution of hyper-reflective speckles at variable depth, it may be useful for diagnosis of each stage of CSC. En face imaging is complementary to cross-sectional imaging and enables visualization of structures that cannot be easily appreciated in cross-sectional images. En-face and B-scan image in SD-OCT provides improved comprehensive topographic information of hyper-reflective speckle types in CSC.
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