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Hyunseung Kang, Hyoung Eun Kim, Jin Hae Lee, Dongkyu Lee, Hyun-Sub Oh, Yong Sung You, Soon Hyun Kim, Oh Woong Kwon; Classification of myopic choroidal neovascularization by fluorescein angiography and optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3757.
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© ARVO (1962-2015); The Authors (2016-present)
To describe morphologic features of myopic choroidal neovascularization (mCNV) on fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD OCT), as well as to correlate them with treatment response.
Sixty-eight eyes of 65 patients with mCNV were included in a retrospective, interventional case series. The images of FA and OCT, and various clinical parameters were examined. mCNV was classified on the basis of FA and OCT findings. The clinical parameters were compared between the types, and correlated with visual acuity.
mCNV was classified into two categories: I, with leakage throughout all phases on FA and definite subretinal thickening on OCT (42 patients), and II, with leakage only on late phase of FA and mild subretinal thickening on OCT (23 patients). Besides age, other clinical parameters such as axial length showed no significant difference between the two types. With mean follow-up of 24 months, type I received a mean of 5.3±3.3 anti-VEGF injections whereas type II received a mean of 6.6±4.4 injections (P=0.171). However, visual improvement after anti-VEGF therapy was statistically significant in type I, but not in type II (+0.19 logMAR, P=0.004 vs. +0.10 logMAR, P=0.183).
mCNV can be classified into two types according to FA and OCT findings. Each type showed different response to anti-VEGF therapy, suggesting that the classification of mCNV may yield important insights into treatment strategy and predicting prognosis.
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