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Christopher Weaver, Steven A Newman; Macular Edema Associated with Anterior Ischemic Optic Neuropathy: An OCT Study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3873.
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Thickening of nerve fiber layer is characteristic of anterior ischemic optic neuropathy. Disc edema, if severe enough, can track into the macula. This may be responsible for some of the decreased vision seen in acute anterior ischemic optic neuropathy. To study the incidence of effect of macular swelling, a retrospective study was undertaken of patients with anterior ischemic optic neuropathy that had OCT of both nerve fiber layer and macula.
A retrospective chart review was performed of longitudinal data from the University of Virginia from December 2005- January 2014 with inclusion criteria consisting of the diagnosis of AION and exclusion criteria of pre-existing macular edema from other comorbidities (n=127).
Of the 127 patients reviewed in this study, 14 had macular edema as demonstrated on macular OCT (11%), which invariably resolved over the course of approximately three months. These patients had improved mean outcomes in visual acuity relative to those without macular edema, in comparison to baseline visual acuity in both groups (p<0.05).
Macular edema associated with AION was found in 11% of patients, with these patients demonstrating improvement in visual acuity at three months compared to those patients who presented without macular edema. Further studies investigating the possible correlation between retinal nerve fiber layer thickness and presence of macular edema are warranted given the uncertainty of the inciting factors in the development of macular edema in AION.
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