June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Multicolour Imaging in Acute Macular Neuro-retinopathy
Author Affiliations & Notes
  • Rashi Arora
    University Hospital of Southampton, Southampton, United Kingdom
    Moorfields Eye Hospital, London, United Kingdom
  • Sara Vaz-Pereira
    Hospital de Santa Maria, Lisbon, Portugal, Lisbon, Portugal
    Faculty of Medicine, University of Lisbon, Portugal, Lisbon, Portugal
  • Gabriella De Salvo
    University Hospital of Southampton, Southampton, United Kingdom
  • Footnotes
    Commercial Relationships Rashi Arora, None; Sara Vaz-Pereira, None; Gabriella De Salvo, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3874. doi:
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      Rashi Arora, Sara Vaz-Pereira, Gabriella De Salvo; Multicolour Imaging in Acute Macular Neuro-retinopathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3874.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To evaluate the role of multicolor imaging (MC) in the diagnosis and follow up of acute macular neuroretinopathy (AMN) and to compare its features to fundus color photograph, near-infrared reflectance (NIR) and spectral domain optical coherence tomography (SD-OCT).

Methods: Color fundus photographs, MC, NIR and SD-OCT were performed in 5 patients who presented with central scotoma and without any specific visible fundus features.

Results: AMN was identified as an area of hypo-reflectance in NIR in 8 eyes of 5 patients. SD-OCT confirmed its location in the outer retina below the outer plexiform layer in 7 eyes (type 2) and above the outer plexiform layer in 1 eye (type 1). Additional MC was performed at baseline in 5 eyes (3 patients) and at follow-up in all eyes. Subsequent follow up demonstrated improvement of symptoms and this was objectively confirmed on both NIR and MC by gradual decrease of hypo-reflectance, with the latest showing higher contrast between the affected and the physiologic areas. SD-OCT showed a partial recovery of the ellipsoid zone in type 2 and inner nuclear layer thinning in type 1.

Conclusions: MC is a new non invasive imaging modality which allows the detection of fine anatomic retinal details. In our patients, MC imaging emerged as a very useful tool in the detection and follow-up of AMN. We believe that, when available, MC should be routinely used to complement SD-OCT in the diagnosis and follow up of this rare inflammatory condition.


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