June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
En-face Optical Coherence Tomography to detect and quantify Geographic Atrophy
Author Affiliations & Notes
  • Elisabetta Pilotto
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Francesca Guidolin
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Rachele Antonini
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Enrica Convento
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Francesco Giuseppe Stefanon
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Luigi Spedicato
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Raffaele Parrozzani
    G.B. Bietti Foundation IRCCS, Roma, Italy
  • Edoardo Midena
    Department of Ophthalmology, University of Padova, Padova, Italy
    G.B. Bietti Foundation IRCCS, Roma, Italy
  • Footnotes
    Commercial Relationships Elisabetta Pilotto, None; Francesca Guidolin, None; Rachele Antonini, None; Enrica Convento, None; Francesco Stefanon, None; Luigi Spedicato, None; Raffaele Parrozzani, None; Edoardo Midena, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3968. doi:https://doi.org/
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      Elisabetta Pilotto, Francesca Guidolin, Rachele Antonini, Enrica Convento, Francesco Giuseppe Stefanon, Luigi Spedicato, Raffaele Parrozzani, Edoardo Midena; En-face Optical Coherence Tomography to detect and quantify Geographic Atrophy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3968. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the possibility to detect and quantify geographic atrophy (GA) secondary to age-related macular by means of en-face spectral-domain optical coherence tomography (en-face OCT) and to compare the GA area to that obtained by means of fundus autofluorescence (FAF).<br />

 
Methods
 

Twenty-four consecutive patients (27 eyes) affected by GA were studied by means of en-face OCT. Both standard (automatic retinal tracking, ART) and enhanced depth imaging (EDI) scanning modalities were performed. The GA areas were measured both on the en-face OCT imaging at the outer retinal (OR) layer and at the choroidal (CH) layer. These areas were compared with the GA areas measured by FAF images. Both short-wavelenght FAF (SW-FAF) and near infrared-wavelenght FAF (NIR-FAF) imaging modalities were performed.<br />

 
Results
 

The intra- and inter-operator agreement in the GA area measurement was excellent at the en-face OCT imaging at the OR layer (ICC= 0.99 in EDI, 0.98 in ART and 0.97 in EDI, 0.98 in ART, respectively). Good concordance was found analyzing the en-face OCT imaging at the CH layer. GA areas measured with both FAF imaging modalities were significantly correlated to those calculated in the en-face SD-OCT imaging at the OR layer level (SW-FAF vs ART-OR and NIR-FAF vs EDI-OR, p=0.0057 and p=0.0036, respectively).<br />

 
Conclusions
 

En-face OCT is a reliable method for the detection and the quantification of GA, particularly when analyzed by means of the en-face OCT imaging at the outer retina, where the loss of photoreceptor layer creates an abrupt transition in OCT reflectivity.<br />

 
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