June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Sealing retinal breaks with FocalSeal® in experimental rhegmatogenous retinal detachment in rabbit eyes
Author Affiliations & Notes
  • Sujin Hoshi
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Fumiki Okamoto
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Yoshimi Sugiura
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Genichiro Kishino
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Tomoya Murakami
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Mikki Arai
    Arai Eye Clinic, Fukuoka, Japan
    Boston Eye Group, Brookline, MA
  • Tatsuo Hirose
    The Schepens Eye Research Institute, Harvard Medical School, Boston, MA
    Boston Eye Group, Brookline, MA
  • Tetsuro Oshika
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships Sujin Hoshi, None; Fumiki Okamoto, None; Yoshimi Sugiura, None; Genichiro Kishino, None; Tomoya Murakami, None; Mikki Arai, None; Tatsuo Hirose, None; Tetsuro Oshika, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 397. doi:
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      Sujin Hoshi, Fumiki Okamoto, Yoshimi Sugiura, Genichiro Kishino, Tomoya Murakami, Mikki Arai, Tatsuo Hirose, Tetsuro Oshika; Sealing retinal breaks with FocalSeal® in experimental rhegmatogenous retinal detachment in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):397.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: FocalSeal® is an absorbable polyethylene glycol-based synthetic hydrogel sealant. This liquid is polymerized under visible xenon illumination, and forms clear, flexible, and firmly adherent hydrogel. This study was conducted to examine the effect of FocalSeal® for sealing retinal breaks in experimental rhegmatogenous retinal detachment in rabbit eyes.

Methods: Experimental retinal detachment with a break was made during a 25-gauge vitrectomy in six rabbit eyes. After performing fluid-air exchange, FocalSeal® was applied to entirely cover iatrogenic retinal breaks, and was polymerized with a 60-second application of xenon light in three rabbit eyes (FS group). Air-fluid exchange was then performed, and operations were finished without intraocular tamponade. In other three eyes, the same procedures were performed without FocalSeal® application (control group). Funduscopic examination and optical coherence tomography (OCT) was carried out in both groups at 1 and 7 days, and 1 and 3 months postoperatively.

Results: The funduscopic examination showed that the retina was reattached in all eyes of the FS group. Meanwhile all three eyes of the control group resulted in proliferative vitreoretinopathy. FocalSeal® was observed on the retinal breaks at 1 and 7 days, but was not observed after 1 month postoperatively.

Conclusions: In our study, FocalSeal® successfully sealed retinal breaks, and repaired experimental rhegmatogenous retinal detachment without intraocular tamponade. FocalSeal® was found to be beneficial to seal retinal breaks during and after vitrectomy for rhegmatogenous retinal detachment.

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