June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Short Duration Transient Visual Evoked Potentials (SD-tVEP) in Unaffected Fellow Eyes of Unilateral Exfoliation Syndrome and Exfoliative Glaucoma Patients
Author Affiliations & Notes
  • Annie Liu
    Einhorn Clinical Research Center, New York Eye and Ear of Infirmary of Mount Sinai, New York, NY
  • Peter H Derr
    Diopsys Inc., Pine Brook, NJ
  • Jessica V Jasien
    Einhorn Clinical Research Center, New York Eye and Ear of Infirmary of Mount Sinai, New York, NY
  • Alberto Omar Gonzalez Garcia
    Diopsys Inc., Pine Brook, NJ
  • Celso Tello
    Einhorn Clinical Research Center, New York Eye and Ear of Infirmary of Mount Sinai, New York, NY
    Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY
  • Robert Ritch
    Einhorn Clinical Research Center, New York Eye and Ear of Infirmary of Mount Sinai, New York, NY
  • Footnotes
    Commercial Relationships Annie Liu, None; Peter Derr, Diopsys Inc. (E); Jessica Jasien, None; Alberto Gonzalez Garcia, Diopsys Inc. (E); Celso Tello, Diopsys Inc. (R); Robert Ritch, Diopsys Inc. (R)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4266. doi:
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      Annie Liu, Peter H Derr, Jessica V Jasien, Alberto Omar Gonzalez Garcia, Celso Tello, Robert Ritch; Short Duration Transient Visual Evoked Potentials (SD-tVEP) in Unaffected Fellow Eyes of Unilateral Exfoliation Syndrome and Exfoliative Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4266.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose
 

To compare the fellow eye of unilateral exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) patients SD-tVEP test results to a set of SD-tVEP parametric reference ranges.

 
Methods
 

The study population was divided into two groups: 1) 24 fellow eyes of 24 unilateral XFS patients (70.0±7.0 yr); and 2) 33 fellow eyes of 33 unilateral XFG patients (71.0±8.1 yr). The fellow eye of the XFG patients did not have clinically evident XFS. The non-exfoliative eye (fellow eye) and exfoliative eye of unilateral XFS and XFG patients had a visual acuity of 20/50 or better. Low Contrast (Lc) and High Contrast (Hc) SD-tVEP’s were recorded using the Diopsys NOVA System (Diopsys, Inc. Pine Brook, NJ). The Michelson contrast of the Lc and the Hc SD-tVEP stimuli were 15% and 85%, respectively. All stimuli was a counterphased modulated checkerboard pattern. The fellow eye’s SD-tVEP responses were compared to four age adjusted SD-tVEP reference ranges,which were established in conformance to the FDA suggested Royston method.. The reference ranges are for the following SD-tVEP’s parameters: Hc N-75-P100 amplitude; Hc P100 latency; Lc N75-P100 amplitude and Lc P100 latency.

 
Results
 

13 of the 24 fellow eyes of the unilateral XFS patients produced SD-tVEP responses outside of at least one of the four SD-tVEP 95%CI reference ranges. 6 eyes failed on one parameter; 4 eyes failed on two parameters and 3 eyes failed on all four parameters. 23 of the 33 fellow eyes of the unilateral XFG patients produced SD-tVEP responses outside of at least one of the four SD-tVEP 95%CI reference ranges. 9 eyes failed on one parameter; 7 eyes failed on two parameters; 5 eyes failed on three parameters and 2 eyes failed on all four parameters. Table 1 shows the SD-tVEP’s parameter’s distribution of the parameters that were outside normal llimits for the XFS and XFG patients.

 
Conclusions
 

The Short-duration transient VEP was capable of identifying abnormal visual functions in a majority of the fellow eyes of unilateral XFS/XFG patients.  

 
Table 1. Distribution of SD-tVEP parameters outside reference range limits.
 
Table 1. Distribution of SD-tVEP parameters outside reference range limits.

 
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