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Graham E Quinn, Charles Barr, Don Bremer, Rae Fellows, Alice Gong, Robert Hoffman, Michael X Repka, Jennifer Shepard, Kelly Wade, Gui-Shuang Ying; Changes in ROP from 1986 to 2013: comparison of 3 US studies. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4322.
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© ARVO (1962-2015); The Authors (2016-present)
Compare infant characteristics and ROP status in 3 clinical studies conducted in a 27-year period in the US.
Common baseline infant characteristics and ROP onset, severity, and time course of ROP were determined using retrospective review of CRYO-ROP and ETROP publications (Ophthalmology 1991;98:1628-40, Pediatrics 2005;116:15-23) and the primary data from e-ROP (JAMA Ophthalmology 2014;132:1178). All three studies enrolled infants with birth weight of <1251g.
The CRYO-ROP study enrolled 4099 infants from January 1986 through November 1987 and the ETROP Trial screened 6998 babies for a prospective study to detect prethreshold ROP from October 2000 through September 2002. The e-ROP examined 1257 infants from May 2011 through October 2013. Across the three studies, mean birth weight (BW) and gestational age (GA) decreased from CRYO-ROP [954g (185), 27.9 (2.2)] to ETROP [907g (205), 27.4 (2.2)] to e-ROP [864g (212), 27.0 (2.2), p<0.0001] with an increase in % infants enrolled <750g (15.8% CRYO, 24.9% ETROP, 33.4% e-ROP, p<0.0001). The percentage of infants who developed ROP varied (65.8% CRYO, 68.0% ETROP, 63.7% e-ROP, p=0.003). Moderately severe ROP (defined as prethreshold or referral-warranted) varied somewhat (17.8% CRYO, 12.3% ETROP, 19.4% e-ROP, p<0.0001), while the onset of any ROP varied little (34.3wks CRYO, 34.1wks ETROP, 34.8wks e-ROP) as did onset of stage 3 ROP and plus disease.
BW and GA of infants enrolled in ROP studies have decreased over the last 27 years in the US, while ROP prevalence and onset of disease are less variable.
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