June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Changes in ROP from 1986 to 2013: comparison of 3 US studies
Author Affiliations & Notes
  • Graham E Quinn
    Pediatric Ophthalmology, Childrens Hosp of Philadelphia, Philadelphia, PA
    Ophthalmology, University of Pennsylvania, Philadelphia, PA
  • Charles Barr
    University of Louisville, Louisville, KY
  • Don Bremer
    Nationwide Children's Hospital, Columbus, OH
  • Rae Fellows
    Nationwide Children's Hospital, Columbus, OH
  • Alice Gong
    Univ Texas - San Antonio, San Antonio, TX
  • Robert Hoffman
    Univ Utah, Salt Lake City, UT
  • Michael X Repka
    Johns Hopkins, Baltimore, MD
  • Jennifer Shepard
    Johns Hopkins, Baltimore, MD
  • Kelly Wade
    Neonatology, University of Pennsylvania, Philadelphia, PA
  • Gui-Shuang Ying
    Ophthalmology, University of Pennsylvania, Philadelphia, PA
  • Footnotes
    Commercial Relationships Graham Quinn, None; Charles Barr, None; Don Bremer, None; Rae Fellows, None; Alice Gong, None; Robert Hoffman, None; Michael Repka, None; Jennifer Shepard, None; Kelly Wade, None; Gui-Shuang Ying, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4322. doi:
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      Graham E Quinn, Charles Barr, Don Bremer, Rae Fellows, Alice Gong, Robert Hoffman, Michael X Repka, Jennifer Shepard, Kelly Wade, Gui-Shuang Ying; Changes in ROP from 1986 to 2013: comparison of 3 US studies. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4322.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Compare infant characteristics and ROP status in 3 clinical studies conducted in a 27-year period in the US.

Methods: Common baseline infant characteristics and ROP onset, severity, and time course of ROP were determined using retrospective review of CRYO-ROP and ETROP publications (Ophthalmology 1991;98:1628-40, Pediatrics 2005;116:15-23) and the primary data from e-ROP (JAMA Ophthalmology 2014;132:1178). All three studies enrolled infants with birth weight of <1251g.

Results: The CRYO-ROP study enrolled 4099 infants from January 1986 through November 1987 and the ETROP Trial screened 6998 babies for a prospective study to detect prethreshold ROP from October 2000 through September 2002. The e-ROP examined 1257 infants from May 2011 through October 2013. Across the three studies, mean birth weight (BW) and gestational age (GA) decreased from CRYO-ROP [954g (185), 27.9 (2.2)] to ETROP [907g (205), 27.4 (2.2)] to e-ROP [864g (212), 27.0 (2.2), p<0.0001] with an increase in % infants enrolled <750g (15.8% CRYO, 24.9% ETROP, 33.4% e-ROP, p<0.0001). The percentage of infants who developed ROP varied (65.8% CRYO, 68.0% ETROP, 63.7% e-ROP, p=0.003). Moderately severe ROP (defined as prethreshold or referral-warranted) varied somewhat (17.8% CRYO, 12.3% ETROP, 19.4% e-ROP, p<0.0001), while the onset of any ROP varied little (34.3wks CRYO, 34.1wks ETROP, 34.8wks e-ROP) as did onset of stage 3 ROP and plus disease.

Conclusions: BW and GA of infants enrolled in ROP studies have decreased over the last 27 years in the US, while ROP prevalence and onset of disease are less variable.


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