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Maurizio Fossarello, Franco Coronella, Giovanni Maria Satta, Pietro Emanuele Napoli; Lipid tear turnover in meibomian gland dysfunction: an optical coherence tomography study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4456.
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© ARVO (1962-2015); The Authors (2016-present)
To assess by means of optical coherence tomography (OCT) the turnover of tear lipids in patients with meibomian gland disease (MGD) and its correlation with classical tear tests.
Forty-two adult patients with MGD were evaluated for abnormalities of ocular surface in the same sequence. It included clinical history, a symptom questionnaire (OSDI = Ocular Surface Disease Index), fluorescein tear break-up time (FTBUT), fluorescein staining of the cornea and conjunctiva graded according to the Oxford system (FSOS), standardized visual scale (SVST), Schirmer I test, and a slit lamp examination of the lid margins and meibomian glands. A novel technique of contrast-enhanced OCT imaging was used to determine the clearance of tear lipids (CoL).
The correlations between CoL and OSDI, FTBUT, FSOS, Schirmer test scores, were found to be statistically significant (p<0.001, Spearman correlation coefficient was 0.82, -0.79, 0.64, -0.5 -0.49, respectively). Moreover, also a significant relationship between CoL and the aqueous tear clearance (SVST) was observed (Spearman correlation coefficient was 0.82, p<0.001).
The reduced dynamics of tear lipids was associated with the MGD. This new finding could lead to a better understanding of the alterations and of the complex pathogenesis of dry eye syndrome.
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