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Jin Young Lee, Kyung Rim Sung; Comparison of rate of RNFL and ganglion cell layer thinning in non-myopic and myopic glaucoma.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4541.
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© ARVO (1962-2015); The Authors (2016-present)
Myopia is known to be a risk factor for development of glaucoma. However, it is not certain whether myopia is a risk factor for fast progression of glaucoma. In our current study, we intended to compare the rates of retinal nerve fiber layer (RNFL) and GC-IPL (ganglion cell-inner plexiform layer) thinning in subgroups of glaucoma patients based on spherical equivalent (SE) by use of spectral domain optical coherence tomography (Cirrus SD-OCT).
A longitudinal, observational study.<br /> 231 eyes from 231 primary open angle glaucoma patients with glaucomatous optic nerve head change and visual field (VF) defect were recruited. The patients were followed up at 6 month intervals with mean follow-up of 4.4 years. The enrolled patients were classified into 3 groups, non myopic group (NMG, > 0 diopter (D)), mild to moderate myopic group (MMG , -6 D<, 0 D>), and high myopic group (HMG, <-6D) according to the SE. Comparisons of RNFL and GC-IPL thinning rate were performed among 3 subgroups using linear mixed effect model.
The mean number of Optic disc/RNFL photographs, SD-OCT, and VF examinations was 7.74±1.37, 7.45±1.67, and 7.67±1.32, respectively. Among 231 eyes, 105 eyes were classified as NMG, 99 eyes as MMG, and 27 eyes as HMG. Average VF mean deviation was -4.64±3.22 in NMG, -6.07±5.84 in MMG, and -4.59±2.82 in HMG, which was not significantly different (p=0.127). Average RNFL thinning rate was -0.739, -0.521 and -0. 645 micron/year, respectively, and those were not significantly different. Among 4 quadrants, HMG groups showed faster RNFL thinning in temporal quadrant (-0.9 micron/year, p=0.04) than NMG (-0.234 micron/year) or MMG (-0.300 micron/year). Average GCIPL thinning rate was not significantly different among three groups.
The rates of OCT RNFL and GC-IPL thinning were not significantly different among subgroups of glaucoma based on refractive error except for temporal quadrant. High myopic glaucoma may progress faster in temporal RNFL sector.
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