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Akiyasu Kanamori, Azusa Akashi, Kaori Ueda, Mari Sakamoto, Yukako Inoue, Yuko Yamada, Makoto Nakamura; The Ability of SD-OCT to Differentiate Early Glaucoma in Highly Myopia from Highly Myopic Control. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4544.
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© ARVO (1962-2015); The Authors (2016-present)
Recent SD-OCT instruments embedded a normative database based on non-highly myopic normal eyes. We assessed the ability of three SD-OCT instruments to differentiate early glaucoma with high myopia from highly myopic controls or non-highly myopic controls.
A total of 54 early glaucomatous eyes (mean deviation<-6.0dB), 54 normal eyes with highly myopia (≦-6.0 D), and 92 normal eyes (non-highly myopia; >-6.0 D) were enrolled in this study. Each participant was imaged using Cirrus, RTVue, and 3D OCT to evaluate the average and quadrant circumpapillaly retinal nerve fiver (cpRNFL ) thicknesses, the macular retinal nerve fiber layer (mRNFL), ganglion cell layer+inner plexiform layer (GCL/IPL), and mRNFL+GCL/IPL (GCC) thicknesses. The areas under the receiver operating characteristic curves (AUCs) were compared among instruments and between subject groups (highly myopic controls vs non-highly myopic controls) for each instrument.
There were no significant differences in AUCs of average cpRNFL thickness and GCC for detecting early glaucoma with highly myopia from highly myopic controls between the instruments. Cirrus and 3D OCT instruments exhibited significantly lower AUCs for average cpRNFL thickness in highly myopic control (Cirrus, 0.974; RTVue, 0.963; 3D OCT, 0.973) than in non-highly myopic control (Cirrus, 0.942; RTVue, 0.953; 3D OCT, 0.933). The highly myopic control showed higher AUCs in the temporal quadrant cpRNFL thickness but lower AUCs in the superior and inferior RNFL thickness compared with non-highly myopic control. AUCs in GCC showed no significant differences between the two sujects groups.
The detecting abilities for early glaucoma with high myopia were almost similar among the instruments. The abilities of the three OCT instruments to differentiate early glaucoma with high myopia from highly myopic control and from non-highly myopic<br /> control were different. Normative database with high myopia should be established for accurate diagnosis of glaucoma in highly myopes
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