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Kenji Suda, Tadamichi Akagi, Hanako Ohashi Ikeda, Hideo Nakanishi, Kyoko Kumagai, Satoshi Morooka, Yugo Kimura, Masanori Hangai, Nagahisa Yoshimura; The Usefulness of Follow Up Mode in Glaucoma Progression Detection. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4550.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the usefulness of the follow-up mode in detecting the glaucoma progression by measuring circumpapillary RNFL (cpRNFL) thickness in SD-OCT
The subjects were prospectively enrolled at Kyoto University Hospital from April 2008. SpectralisTM HRA+OCT system (Heidelberg Engineering, Heidelberg, Germany) were performed repeatedly. The subjects examined at least 3 times for 12 months were included in the following analysis. Linear mixed model was conducted to evaluate the longitudinal trends of the measurement.
Two hundred and thirty three eyes of 149 patients were finally included in this study. One hundred and eight eyes of 62 patients (Group A, mean age ± standard deviation, 61.5 ± 10.9 years) were examined using the follow-up mode in Spectralis OCT. One hundred and twenty five eyes of 87 patients (Group B, mean age ± standard deviation, 47.1 ± 11.4 years) were examined without using the follow-up mode. Linear mixed models showed estimated average rate of global cpRNFL change per year was -1.29 μm /year in Group A (95% CI -2.00 μm/year to -0.57 μm/year) and -1.17 μm /year in Group B (95% CI -2.47 μm/year to 0.13 μm/year), suggesting that significant negative trends over time were detected in Group A but not in Group B. In sectorial analysis, significant negative trends were detected for all the sectors in Group A (-2.37 μm/year to -0.80 μm/year), but significant positive trends were detected for some sectors in Group B (-4.53 μm/year to 2.80 μm/year).
In evaluating the glaucoma progression by cpRNFL thickness in SD-OCT, the use of the follow-up mode may allow more accurate detection of glaucoma progression.
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