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Takeo Fukuchi, Tetsuya Togano, Yuuta Sakae, Miho Hirashima, Ryoko Igarashi, Takaiko Yoshino; The Features of Glaucomatous Retinal Nerve Fiber Bundles Observed by En-face Swept-Source Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4553.
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© ARVO (1962-2015); The Authors (2016-present)
To observe the features of glaucomatous retinal nerve fiber bundles (NFB) using en-face swept-source optical coherence tomography (SS-OCT).
Fifteen eyes of normal volunteers and 75 eyes of patients with open-angle glaucoma (OAG) were analyzed. Three-dimensional 6x6 mm cube raster scans of the macula and optic nerve head (ONH) were obtained using SS-OCT at a wavelength of 1,050 nm. NFBs were observed with an image browser software after flatten processing against the inner limiting membrane (ILM). Moving the cross-sectional section from the vitreous to the retina, retinal NFBs were visualized just under the ILM. These images were compared to the results of the macular analysis with spectral domain OCT(SD-OCT)and visual field results with Humphrey Visual Field Analyzer(HFA) .
OAG patients were 53.0±11.0 years old(mean ± standard deviation)with a MD of -11.1±7.3 dB as measured using a 30/24-2 HFA SITA Standard．In all normal eyes, retinal NFBs were clearly identified around the ONH, macula, and the temp zone. While NFB defects were characteristic around the ONH, persistent NFBs were detectable around the fovea in 62 eyes (82.6%) with OAG. These results basically corresponded to the visual field data. The vitreoretinal interface may influence the image, and an epiretinal membrane would be an unsuitable condition to the system.
The detailed fine structure of NFB defects around the ONH and rarely persistent NFBs around the fovea corresponding to the visual field can be identified using en face SS-OCT.
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