June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Relationship between the Peripapillary Choroidal Thickness and Retinal Nerve Fiber Layer Thickness: A Population-based Study
Author Affiliations & Notes
  • Preeti Gupta
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, Singapore
  • Jing Tian
    Department of Ophthalmology for the University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, FL
  • Pina Marziliano
    School of Electrical and Electronic Engineering Division of Information Engineering, Nanyang Technological University, Singapore, Singapore
  • Carol Yim-lui Cheung
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, Singapore
  • Baskaran Mani
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, Singapore
  • Ecosse Luc Lamoureux
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
  • Gemmy Cheung
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
  • Tin Aung
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, Singapore
  • Tien Yin Wong
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, Singapore
  • Ching-Yu Cheng
    Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships Preeti Gupta, None; Jing Tian, None; Pina Marziliano, None; Carol Cheung, None; Baskaran Mani, None; Ecosse Lamoureux, None; Gemmy Cheung, None; Tin Aung, None; Tien Wong, None; Ching-Yu Cheng, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4579. doi:https://doi.org/
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      Preeti Gupta, Jing Tian, Pina Marziliano, Carol Yim-lui Cheung, Baskaran Mani, Ecosse Luc Lamoureux, Gemmy Cheung, Tin Aung, Tien Yin Wong, Ching-Yu Cheng; Relationship between the Peripapillary Choroidal Thickness and Retinal Nerve Fiber Layer Thickness: A Population-based Study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4579. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Peripapillary choroidal thickness (PPCT) may be another imaging measure of early glaucoma damage since vascular factors have been suggested to play a role in glaucoma development. This study describes the relationship between PPCT and retinal nerve fiber layer (RNFL) thickness in a population-based sample of non-glaucomatous subjects.

Methods: Subjects were recruited from the Singapore Malay Eye Study during their follow-up examination and underwent standardized ophthalmic examination, including RNFL and peripapillary choroidal imaging using spectral domain optical coherence tomography (SD-OCT). RNFL thicknesses (average, and quadrants) were measured using Cirrus OCT (Carl Zeiss Meditec, Dublin, USA). PPCT (average and quadrants) were measured using Spectralis SD-OCT with enhanced depth imaging (Heidelberg Engineering, Heidelberg, Germany), and derived by a customized automated choroidal segmentation software. Of a total of 478 subjects (904 eyes) recruited, 61 eyes were excluded because of clinical features compatible with glaucoma and other factors, leaving 435 subjects (843 eyes) for analysis. Associations between PPCT and RNFL thickness were assessed using linear regression models with generalized estimating equations to account for the inter-eye correlations.

Results: Of the 435 included subjects (843 non-glaucomatous eyes), 39% were men, and the mean (SD) age was 66.7 (10.5) years. The mean PPCT was 135.59 ± 56.74 µm and the mean RNFL thickness was 92.92 ± 11.41 µm. Peripapillary choroid was thickest (150.04 ± 59.72 µm) at superior and thinnest (110.71 ± 51.61 µm) at inferior quadrant, whereas RNFL was thickest (118.60 ± 19.83 µm) at inferior and thinnest (67.36 ± 11.36 µm) at temporal quadrant. We found that thicker PPCT was independently associated with thicker RNFL thickness globally (regression coefficient [β] = 0.24 µm for one µm increase in PPCT, p = 0.002), and in the inferior (β = 0.05, p = 0.001) and superior (β = 0.04, p<0.001) quadrants, after adjusting for age, gender, axial length and variables with p≤0.05 in univariate models.

Conclusions: There is an independent positive association between inferior, superior and average PPCT and RNFL thickness. This structure-structure relationship may provide an additional diagnostic tool in glaucoma risk assessment in clinical settings.

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