June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Reference Ranges for Fixed Protocol Short Duration Transient Visual Evoked Potentials Parameter of Healthy Eyes
Author Affiliations & Notes
  • Peter H Derr
    Diopsys Inc, Pine Brook, NJ
  • Alberto Gonzalez-Garcia
    Diopsys Inc, Pine Brook, NJ
  • Anna Shengelia
    New York Glaucoma Research Institute, New York, NY
  • Jason L Chien
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
    George Washington University School of Medicine and Health Sciences, Washington, DC
  • Mark Ghassibi
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
    George Washington University School of Medicine and Health Sciences, Washington, DC
  • Celso Tello
    New York Glaucoma Research Institute, New York, NY
    Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, Hofstra North Shore-LIJ School of Medicine, Hempstead, NJ
  • Robert Ritch
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
  • Footnotes
    Commercial Relationships Peter Derr, Diopsys Inc. (E); Alberto Gonzalez-Garcia, Diopsys Inc. (E); Anna Shengelia, None; Jason Chien, None; Mark Ghassibi, None; Celso Tello, Diopsys Inc. (C); Robert Ritch, Diopsys Inc. (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 461. doi:https://doi.org/
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      Peter H Derr, Alberto Gonzalez-Garcia, Anna Shengelia, Jason L Chien, Mark Ghassibi, Celso Tello, Robert Ritch; Reference Ranges for Fixed Protocol Short Duration Transient Visual Evoked Potentials Parameter of Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):461. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the responses of Fixed Protocol Short Duration Transient Visual Evoked Potentials (SD-tVEP) on healthy subjects, to obtain the distribution of these parameters, and to establish expected reference ranges.

 
Methods
 

95 healthy eyes were randomly selected (95 subjects). Inclusion criteria was: best corrected visual acuity 20/30 or better, spherical refraction within ±5.00 D, cylinder correction within ±3.00 D, normal Standard Automated Perimetry, normal slit lamp biomicroscopy, intraocular pressure ≤22 mmHg , normal stereoscopic disk photos, normal retinal nerve fiber layer thickness by optic coherence tomography, normal dilated fundus examination. SD-tVEP’s were recorded using the Diopsys NOVA System . Each eye was stimulated with a 15% (Lc) and 85% (Hc) Michelson contrast checkerboard pattern. Test duration was 30 seconds/eye and each test resulted in a low and high contrast response . Each response’s P100 latency and N75-P100 amplitude was evaluated. Reference ranges were calculated: Lc Amplitude, Lc Latency, Hc Amplitude and Hc Latency. The reference ranges were validated for normal distribution of the residuals (Observed values - Predicted values) across the entire age range and for three equal sized subgroups based on age.

 
Results
 

Study population demographics were: 45.3% male; 54.7% female; 75.8% Caucasian; 2.1% African American; 17.9% Hispanic; and 4.2% Asian. The age range was 21 to 81 years old. Table 1 is the SD-tVEP parameter age adjusted reference ranges with ±95% CI.

 
Conclusions
 

SD-tVEP low and high contrast fixed protocol reference ranges with (-/95%CI) will provide the clinician the ability to compare a patient’s SD-tVEP results to an age adjusted mean value with upper and lower limits.  

 
Table 1. SD-tVEP parameter age adjusted reference ranges with ±95%CI.
 
Table 1. SD-tVEP parameter age adjusted reference ranges with ±95%CI.

 
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