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June-Gone Kim, Junyeop Lee, Soo Geun Joe, Joo Yong Lee, Young Hee Yoon; Predictive factors for microvasuclar recovery after treatments in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4682.
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© ARVO (1962-2015); The Authors (2016-present)
To identify factors associated with microvascular recovery after intravitreal bevacizumab and/or panretinal photocoagulation (PRP) in diabetic retinopathy (DR).
We retrospectively reviewed 320 eyes of DR which treated with intravitreal bevacizumab and/or PRP. Two consecutive fluorescein angiography (FA) of each eye were compared. Number of microaneurysms and area of capillary non-perfusion were calculated automatically using ImageJ software. Microvascular recovery was defined as marked reduction in the numbers of microaneurysm (< 20%), or marked reduction in the area of capillary non-perfusion (< 50%) in 45 degree fields, or complete regression of new vessels in ETDRS 7 standard fields. Baseline FA findings and changes of ocular and systemic factors were analyzed.
Twenty-eight (8.8%) of the 320 total eyes were found to meet the criteria of microvascular recovery after treatments. Multivariate analysis revealed that the presence of telangiectasis (P = .003) and late disc leaking (P = .007) on baseline FA and the reduction of glycated hemoglobin (P = .005) during follow-up period were predictive factors of microvascular recovery after treatments. Although microvascular recovery group presented significant improvement of BCVA after treatments, baseline BCVA could not predict microvascular recovery after treatments.
Telangiectasis or late disc leaking on baseline FA and improved glycemic control positively predicted microvascular recovery after treatments in DR.
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