Abstract
Purpose:
To identify factors associated with microvascular recovery after intravitreal bevacizumab and/or panretinal photocoagulation (PRP) in diabetic retinopathy (DR).
Methods:
We retrospectively reviewed 320 eyes of DR which treated with intravitreal bevacizumab and/or PRP. Two consecutive fluorescein angiography (FA) of each eye were compared. Number of microaneurysms and area of capillary non-perfusion were calculated automatically using ImageJ software. Microvascular recovery was defined as marked reduction in the numbers of microaneurysm (< 20%), or marked reduction in the area of capillary non-perfusion (< 50%) in 45 degree fields, or complete regression of new vessels in ETDRS 7 standard fields. Baseline FA findings and changes of ocular and systemic factors were analyzed.
Results:
Twenty-eight (8.8%) of the 320 total eyes were found to meet the criteria of microvascular recovery after treatments. Multivariate analysis revealed that the presence of telangiectasis (P = .003) and late disc leaking (P = .007) on baseline FA and the reduction of glycated hemoglobin (P = .005) during follow-up period were predictive factors of microvascular recovery after treatments. Although microvascular recovery group presented significant improvement of BCVA after treatments, baseline BCVA could not predict microvascular recovery after treatments.
Conclusions:
Telangiectasis or late disc leaking on baseline FA and improved glycemic control positively predicted microvascular recovery after treatments in DR.