June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
A comparative analysis of changes in visual field sensitivity in type 2 diabetes
Author Affiliations & Notes
  • Faran Sabeti
    Vision Science, Australian National University, Bruce, ACT, Australia
  • Rakesh Mallikarjunan
    Medical School, Australian National University, Acton, ACT, Australia
  • Christopher Nolan
    Medical School, Australian National University, Acton, ACT, Australia
  • Corinne F Carle
    Vision Science, Australian National University, Bruce, ACT, Australia
  • Andrew James
    Vision Science, Australian National University, Bruce, ACT, Australia
  • Ted Maddess
    Vision Science, Australian National University, Bruce, ACT, Australia
  • Footnotes
    Commercial Relationships Faran Sabeti, None; Rakesh Mallikarjunan, None; Christopher Nolan, None; Corinne Carle, None; Andrew James, None; Ted Maddess, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4685. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Faran Sabeti, Rakesh Mallikarjunan, Christopher Nolan, Corinne F Carle, Andrew James, Ted Maddess; A comparative analysis of changes in visual field sensitivity in type 2 diabetes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4685.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

The aim of the study was to investigate the effect of diabetic retinopathy (DR) severity on multifocal pupillographic objective perimetry (mfPOP) compared with Humphrey Matrix and short wavelength automated perimetry (SWAP).

 
Methods
 

Seventy eyes of 35 subjects with type 2 diabetes, with no to minimal (sev1, n=40), and moderate to severe (sev2) DR (n=30) based on ETDRS fundus photos, and 20 age and sex-matched control subjects were recruited from The Canberra Hospital. At visit one participants were randomly tested with a Macularfield (±15° eccentricity from fixation) and Widefield (±30° eccentricity) mfPOP stimulus protocols and Humphrey Matrix perimetry. At visit 2 the mfPOP protocols were repeated, followed by SWAP. MfPOP stimulus protocols utilized yellow luminance-balanced stimuli with a peak luminance of 150 and 288 cd/m2 for the Widefield and Macularfield protocols respectively. Visual sensitivity were calculated globally and for four eccentricities (3°, 9°, 15° and 21°) for Matrix and SWAP perimetry and five eccentricities (4°, 8°, 12°, 18° and 24°) for mfPOP. Generalised mixed models were used to determine the effect of retinopathy severity on visual field sensitivity.

 
Results
 

The mean effect of disease on Matrix mean deviation (MD) showed a significant reduction in sensitivity of -0.63 dB ± 2.7 for sev1; and -1.12 dB ± 3.0 for sev2 patients respectively compared with controls: 1.25 dB ± 2.3 (mean effect ± SE, all p<0.05). SWAP MDs were were also significantly reduced for sev1: -2.37 dB ± 3.8 and sev2: -2.44 dB ± 3.7 compared with controls: 0.11 dB ± 1.0 (both p<0.05). Ring-wise means showed reductions in sensitivity with increasing eccentricity for both sev1 and sev2 groups but did not reach significance for SWAP and Matrix. The effect of sev1 and sev2 DR on mfPOP significantly reduced amplitude deviations across the outer 3 rings, with the largest deviation presenting in the outermost ring, for both sev1 (-1.40 dB ± 0.53, p<0.05) and sev2(-3.15 dB ± 0.09, p<0.05) group in the Widefield stimulus protocol. Time to peak mfPOP responses were not significantly delayed across any rings.

 
Conclusions
 

MfPOP may be more sensitive to visual field loss than SWAP and matrix in type 2 diabetic patients with minimal to no signs of DR (n=40). Further investigation of prognostic biomarkers in mfPOP identifying eyes at risk of retinopathy progression is warranted.

 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×