June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Intravitreal Autologous Bone Marrow Derived Stem Cells in Ischemic Macular Edema - Results after 6 Months Follow-up
Author Affiliations & Notes
  • Monique Viana de Sousa
    Ophtalmology, Faculdade de Medicina de Ribeirao Preto USP, Ribeirao Preto, Brazil
  • Rodrigo Jorge
    Ophtalmology, Faculdade de Medicina de Ribeirao Preto USP, Ribeirao Preto, Brazil
  • Andre Messias
    Ophtalmology, Faculdade de Medicina de Ribeirao Preto USP, Ribeirao Preto, Brazil
  • Carina Costa Cotrim
    Ophtalmology, Faculdade de Medicina de Ribeirao Preto USP, Ribeirao Preto, Brazil
  • Murilo Wendeborn Rodrigues
    Ophtalmology, Faculdade de Medicina de Ribeirao Preto USP, Ribeirao Preto, Brazil
  • Rubens C Siqueira
    Ophtalmology, Faculdade de Medicina de Ribeirao Preto USP, Ribeirao Preto, Brazil
  • Footnotes
    Commercial Relationships Monique Sousa, None; Rodrigo Jorge, None; Andre Messias, None; Carina Costa Cotrim, None; Murilo Rodrigues, None; Rubens Siqueira, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4718. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Monique Viana de Sousa, Rodrigo Jorge, Andre Messias, Carina Costa Cotrim, Murilo Wendeborn Rodrigues, Rubens C Siqueira; Intravitreal Autologous Bone Marrow Derived Stem Cells in Ischemic Macular Edema - Results after 6 Months Follow-up. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4718. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To investigate the effects and the safety of intravitreal autologous bone marrow-derived stem cells (auto-BMSC) in retinal vascular diseases with ischemic maculophaty.

Methods: Prospective, non-randomized clinical trial, including 15 patients (15 eyes) with ischemic macular edema due to diabetic retinopathy (DR), central retinal vein occlusion (CRVO) or central retinal artery occlusion (CRAO). Patients showed best-corrected visual acuity (BCVA) of 20/50, or worse, and no history of cancer or other ocular condition. In proliferative diabetic retinopathy (PDR), only patients without active neovascularization were included. Patients underwent intravitreal injection of approximately 106 CD 34+ autologous bone marrow-derived cells (0.1 ml), and were evaluated before injection (baseline), and monthly during follow-up. A comprehensive ophthalmological evaluation was performed, including BCVA measurement, full field electroretinography (ERG - Diagnosys LLC), multifocal electroretinography (mfERG - Diagnosys LLC), and microperimetry (MAIA - Centervue) to access central (20 degrees) retinal sensitivity average threshold (AT), and the bivariate contour ellipse area (BCEA) as a measure of the fixation stability, to evaluate retinal function. Fluorescein angiography (FA) was performed to evaluated foveal avascular zone area (FAZA) and neovascularization, and optical coherence tomography (s-OCT Heidelberg Engineering), to assess retinal structure and measure macular thickness.

Results: So far, 6 eyes completed 6 month of follow-up. CRAO: n=1, CRVO: n=1 and DR: n=4. No significant changes were observed during follow-up for any measurement. Mean ± SE BCVA was 1.05 ± 0.15 at baseline and 1.10 ± 0.14 logMAR at 6 months (P = 0.3655); central macular thickness on OCT was 468.00 ± 50.89 µm at baseline and 433.29 ±65.68 µm at 6 months (P = 0.3743) and FAZA was 5.33 ± 0.84 degrees2 at baseline and 5.97 ±0.98 degrees2 at 6 months (P = 0.5974). No significant ocular or systemic adverse effects were observed.

Conclusions: Intravitreal CD 34+ autologous bone marrow-derived cells seems to be safe in eyes with ischemic macular edema in retinal vascular diseases, and in this small cohort was associated with no significant functional or structural retinal changes in six months. A larger number of cases and a longer follow-up are needed to confirm these findings.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×