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Seong-Won Yang, Saemi Park; Plasma surface modification of porous polyethylene implants in orbital reconstruction. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4756.
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© ARVO (1962-2015); The Authors (2016-present)
Various alloplastic materials are used in orbital wall reconstruction. We investigated the pre-osteoblast adhesion and osseointegration on porous polyethylene (PE) with hydrophobic surface using a plasma surface treatment.
Surface modified PE was prepared by oxygen or nitrogen plasma. After plasma treatment, adhesion and differentiation of MC3T3-E1 cells was evaluated using a MTT assay and alkaline phosphatase (ALP) activity respectively. A total of 10 white rabbits orbital medial, inferior, and maxilla bone were exposed. After that, pre-treated implant was inserted. Micro-CT, Immunostaining were performed before exposure, 4 weeks, and 8 weeks, afterward to allow for serial comparisons.
Plasma-treated PE implants significantly increased cell adhesion and ALP activity and up-regulated expression of osteogenesis-related genes such as alkaline phosphatase, osteopontin and osteocalcin in MC3T3-E1 cells. In vivo results showed that plasma-treated samples demonstrate the good bone formation than the control.<br />
Plasma-treated porous polyethylene can be used as a useful material for Orbital fracture.
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