June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
OPTIC NERVE HEAD AND CHOROIDAL VASOREACTIVITY TO HYPOXIA IN HEALTHY HUMANS
Author Affiliations & Notes
  • Mathilde Gallice
    GRENOBLE, Universitary Hospital, Grenoble, France
  • Thierry Zhou
    GRENOBLE, Universitary Hospital, Grenoble, France
  • Florent Aptel
    GRENOBLE, Universitary Hospital, Grenoble, France
    INSERM U1042, Grenoble, France
  • Samuel Verges
    GRENOBLE, Universitary Hospital, Grenoble, France
    INSERM U1042, Grenoble, France
  • Martial Henry Geiser
    Haute Ecole Valaisanne, Sion, Switzerland
  • Jean Paul Romanet
    GRENOBLE, Universitary Hospital, Grenoble, France
  • Christophe Chiquet
    GRENOBLE, Universitary Hospital, Grenoble, France
    INSERM U1042, Grenoble, France
  • Footnotes
    Commercial Relationships Mathilde Gallice, None; Thierry Zhou, None; Florent Aptel, None; Samuel Verges, None; Martial Henry Geiser, None; Jean Paul Romanet, None; Christophe Chiquet, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4858. doi:
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      Mathilde Gallice, Thierry Zhou, Florent Aptel, Samuel Verges, Martial Henry Geiser, Jean Paul Romanet, Christophe Chiquet; OPTIC NERVE HEAD AND CHOROIDAL VASOREACTIVITY TO HYPOXIA IN HEALTHY HUMANS. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4858.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Optic nerve head (ONH) and choroidal (Ch) vasoreactivity to hypoxia is not clearly defined, although it is a common pathological situation in diabetic retinopathy, retinopathy of prematurity, open-angle glaucoma or in systemic diseases. We measured ocular blood flow changes in response to acute hypoxia in healthy humans.

Methods: Using confocal laser Doppler flowmetry, ONH and Ch blood flow were measured under hypoxia condition during 15 minutes (FiO2 10,5%) in order to reach a stable 85% SpO2. PetCO2, blood pressure, and respiratory rate were monitored during the experiment.

Results: Fourteen young (28±6 years ) healthy subjects were included. In response to 85% hypoxia, ONH blood flow increased of +11% [−2.4; 34] (median and interquartiles interval, p=0.08) mainly due to an increase in ONH velocity +18% [6; 27] (p=0.004). Choroidal LDF parameters did not significantly differ during hypoxia (p=0.2 for Ch flow, p=0.3 for Ch volume, and p=0.12 for Ch velocity). Respiratory rate or arterial pressure did not significantly change during experiment.

Conclusions: The response of ONH to hypoxia is close to that described for the retina. The absence of choriocapillaris vasoreactivity to hypoxia, despite a significant decrease in tissue oxygen partial pressure, could be explained by the conterbalanced vasoconstriction associated with the activation of the autonomic nervous system during hypoxia.

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