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David Jesus Islas, Jasbeth Ledesma Gil, Alejandro Navas, Gerardo Ledesma, María Enriqueta Hofmann, Pamela Cepeda; Angular structure-assessment in children with congenital glaucoma and healthy controls using anterior segment optical coherence tomography.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4972.
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© ARVO (1962-2015); The Authors (2016-present)
Anterior segment assessment using ancillary tests has become an elementary tool for documenting and supporting diagnosis of anterior segment diseases (specially in the absence of clear media) for clinicians and ophthalmologists. Nonetheless, most of these studies require full patient’s cooperation, thus, can be difficult to perform in pediatric population. We performed a prospective, observational, clinical case-control study on a pediatric population of cases with congenital glaucoma and healthy controls in order to stablish baseline parameters and to evaluate anatomic differences between both subgroups.
We included 56 eyes of 28 patients with congenital glaucoma and 70 eyes of 37 healthy children in the control group. We performed in all cases an anterior segment optical coherence tomography (OCT Visante ®, Carl Zeiss Meditec AG, Jena, Germany) and we used an image storage database of the following measurements: angular opening distance at 1800 and 00 (AOD500), trabecular-iris space area at 180 0 and 00 (TISA500), anterior chamber depth (ACD), central corneal thickness (CCT) and scleral spur distance (SSD). T test and STATA 8.0 were used for statistical analysis.
Almost two-thirds of the patients were male (64.86% vs. 64.28% for congenital glaucoma and controls). The mean age was 119.90+57.49 months for congenital glaucoma and 90.18+43.66 months for controls. No statistical differences between groups were found for AOD500 (P=0.487 at 1800 and P=0.421 at 00) and TISA500 (P=0.061 at 1800 and P=0.954 at 00), whereas differences for anterior chamber depth, pachymetry and scleral spur distance were significant (P=0.001).
To our knowledge there are no current reports on anterior segment angular-structure parameters for pediatric population. Anterior segment ocular coherence tomography is a non-invassive, cost-effective, and feasible tool that could be performed in children for early diagnosis, prognosis and treatment of anterior segment diseases, specially in the absence of clear media.
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