Iridocorneal Angle in Neonates Interoperator and Intraoperator Reliability using Spectral Domain Optical Coherence Tomography

Abstract

Purpose: To assess the interoperator and intraoperator reliability of spectral domain (SD) optical coherence tomography (OCT) measurements of iridocorneal angle in neonates.

Methods: We included children under 1 year old, a total of 20 randomly chosen consecutive eyes. SD-OCT was used without sedation to capture the iridocorneal angle. Measurements analyzed with custom software were: Angle opening in degrees (AOG); Angle opening distance (AOD₅₀₀) at 500 µm; and angle opening distance (AOD₇₅₀). In order to evaluate intra-test reliability, measurements were done on the same eye at two time points, over a 7-day period.

Results: Results: Mean patient age was 5.15(±2.9) months (range, 1-10 months); 12 (30%) were male. Mean angle opening in degree (33.5° and 31.45°) ,mean angle opening distance at 500 µm ranged (430.25 and 416 µm) and mean angle opening distance at 750 µm (513.7 and 512.05 µm). Intraobserver Intraclass coefficient correlation ranged from 0.890-0.992 (p-value <0.05). In Bland-Altman analysis, interoperator with no difference.(p>0.05)

Conclusions: Conclusions. This is the first study to demonstrate the reliability of spectral domain (SD) optical coherence tomography (OCT) measurements of iridocorneal angle in neonates. The use of SD-OCT to measure the iridocorneal angle in neonates proved to be a reliable method interoperator and intraoperator.