Abstract
Purpose:
To investigate anterior segment optical coherence tomography (AS-OCT) parameters that can predict laser peripheral iridotomy (LPI) outcome.
Methods:
We retrospectively reviewed the medical records of primary angle closure or primary angle closure glaucoma (PAC(G)) patients who underwent LPI between 2009 and 2012. The relevant pre-LPI AS-OCT images were analyzed using customized software. The parameters investigated were anterior chamber depth (ACD), lens vault (LV), anterior vault (AV) and relative lens vault (rLV = LV/AV), trabecular iris angle (TIA), angle opening distance (AOD), and trabecular iris space area (TISA). Successful LPI was defined as at least 20% lowering of intraocular pressure with no additional medical, laser, or surgical interventions.
Results:
Fifty-two eyes of 52 subjects had undergone LPI. Over a mean follow up of 40.85±16.87 months, successful LPI was achieved for 51.92% of the subjects. The ACD (p=0.010), AV (p=0.048), rLV (p=0.039), ACA (p=0.013), TISA 500 (p=0.026), TISA 750 (p=0.010), AOD500 (p=0.019) and AOD750 (p=0.019) between the successful and unsuccessful groups were significantly different. In the multivariate analysis results, rLV (p=0.039) and TISA750 (p=0.043) were the most significant predictors of successful post-LPI outcome.
Conclusions:
Successful LPI outcome is associated with narrower pre-LPI angle (decreased TISA750) and increased rLV.