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Sam Seo, Ki Ho Park, Chong Eun Lee, Young Kook Kim, Jin Wook Jeoung, Dong Myung Kim, Kyoo Won Lee; Anatomic factors influencing laser peripheral iridotomy outcome in primary angle closure. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4993.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate anterior segment optical coherence tomography (AS-OCT) parameters that can predict laser peripheral iridotomy (LPI) outcome.
We retrospectively reviewed the medical records of primary angle closure or primary angle closure glaucoma (PAC(G)) patients who underwent LPI between 2009 and 2012. The relevant pre-LPI AS-OCT images were analyzed using customized software. The parameters investigated were anterior chamber depth (ACD), lens vault (LV), anterior vault (AV) and relative lens vault (rLV = LV/AV), trabecular iris angle (TIA), angle opening distance (AOD), and trabecular iris space area (TISA). Successful LPI was defined as at least 20% lowering of intraocular pressure with no additional medical, laser, or surgical interventions.
Fifty-two eyes of 52 subjects had undergone LPI. Over a mean follow up of 40.85±16.87 months, successful LPI was achieved for 51.92% of the subjects. The ACD (p=0.010), AV (p=0.048), rLV (p=0.039), ACA (p=0.013), TISA 500 (p=0.026), TISA 750 (p=0.010), AOD500 (p=0.019) and AOD750 (p=0.019) between the successful and unsuccessful groups were significantly different. In the multivariate analysis results, rLV (p=0.039) and TISA750 (p=0.043) were the most significant predictors of successful post-LPI outcome.
Successful LPI outcome is associated with narrower pre-LPI angle (decreased TISA750) and increased rLV.
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