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Victor Chen, Don Byongdo Kim, Gloria Wu; Drusen in the Asian pediatric population aged 6-18 yrs. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5130. doi: https://doi.org/.
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Non-exudative age related macular degeneration has been reported to be increased in Asians in previous studies Drusen have been reported in adults <55yrs, but is less studied in pediatric patients (pts). This study assesses the appearance of drusen in Asian pediatric patients in a retina practice in San Jose, CA, where 50% of the population is of Asian descent.
Using the EHR, eClinicalWorks, from a retina practice from 1/2013-11/2014, pts were identified who were aged 6-18 years, with CPT code 92250 and non-retina ICD diagnosis codes with Va=20/15-20/30. TRC-50EX Topcon camera, OIS winstation-XP, zoom 3x feature were used to examine color and red-free photos. The OIS winstation AREDS retinal grid was used to identify drusen and measure drusen size. The grid was superimposed on the fundus photo, centered at the fovea. Using the OIS Topcon software 3x zoom feature, all quadrants, para and perifoveal regions were inspected for drusen. This was done in all the fundus photographs with the above criteria. Inclusion criteria: no macular disease, best corrected visual acuity 20/15-20/30. Age range 6-18 years old. Exclusion criteria: poor quality fundus photos, macular disease lesions or macular diagnoses.
A total of 54 patients met our inclusion criteria. 35 Asian/South Asian, 8 Caucasian, 3 Hispanic, 1 African American, and 7 “Other” race. Of those 54, we examined the 35 Asian patients. Average age = 12.14, sd=4.19, males n=18, avg male age=11.61, sd=4.38, females n=17, avg female age=12.71, sd=4.04.<br /> 70 photographs were examined in total. 4/70 photos were excluded due to poor vision in the photographed eye. No drusen in 24/70 eyes. The remaining 42/70 eyes had drusen from 25 patients. 17 pts had drusen in both eyes.<br /> Patients with drusen ranged from 6-18 yrs in age. Average number of drusen per eye OD = 3.7 ± 2.8. Average number of drusen per eye OS = 3.0 ± 2.3. In total, 135 drusen were counted, all fewer than 65um in diameter (C0 on the AREDS grid). 115 of 135 drusen appeared in the outer quadrants vs. 20 found in the inner quadrants. 74 drusen (55%) appeared in right eyes vs 61 drusen (45%) in left eyes.
Drusen can be found in Asian children as early as age 6. A majority of drusen were found in the perifoveal quadrants.
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