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Seigo Yoneyama, Yoichi Sakurada, Wataru Kikushima, Fumihiko Mabuchi, Hiroyuki Iijima; Genetic and clinical factors associated with choroidal vascular hyperpermeability and subfoveal choroidal thickness in polypoidal choroidal vasculopathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5134.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate genetic and clinical factors associated with choroidal vascular hyperpermeability (CVH) and subfoveal choroidal thickness (SCT) in eyes with treatment-naïve polypoidal choroidal vasculopathy (PCV).
We studied the consecutive 149 patients with PCV. Presence or absence of CVH was evaluated on indocyanine green angiography (ICGA). Subfoveal choroidal thickness (SCT) and axial length was measured by spectral domain optical coherence tomography and optical biometry, respectively. Variants of ARMS2 (rs10490924) and CFH (rs800292 and rs1329428) were genotyped using TaqMan technology.
Subfoveal choroidal thickness was correlated with axial length and age (p=0.001 and p=0.02, respectively).Though there was not a significant difference in SCT among CFH(rs800292) genotypes, there was a statistical difference in SCT among CFH(rs1329428) and ARMS2(rs10490924) genotypes. (p=0.002 and p=0.006, stepwise regression analysis, respectively).Among 149 eyes with PCV, 35 (23.5%) eyes exhibited CVH on ICGA. There was a significant lower frequency of risk variants in CFH(rs1329428) and ARMS2(rs10490924) in patients with CVH than patients without CVH (p=0.029 and p=0.005, stepwise regression analysis, respectively).
In addition to axial length and age, SCT in eyes with PCV were associated with both genetic variants in CFH and ARMS2 gene. Patients with CVH might have a weaker effect on both genetic variants than patients without CVH.
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