June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Changes in Subretinal Drusenoid Deposits (SDD) During Progression to Geographic Atrophy (GA) and Choroidal Neovascularization (CNV) in Age-Related Macular Degeneration (AMD)
Author Affiliations & Notes
  • Vivek Kumar
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Patrick A Kaszubski
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Tal Ben Ami
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Celine Saade
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Ana Rita Santos
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
  • Rufino Silva
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
    Department of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal
  • Maria Luz Cachulo
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
    Department of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal
  • Jose G Cunha-Vaz
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
  • Theodore Smith
    Department of Ophthalmology, New York University School of Medicine, New York, NY
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5151. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Vivek Kumar, Patrick A Kaszubski, Tal Ben Ami, Celine Saade, Ana Rita Santos, Rufino Silva, Maria Luz Cachulo, Jose G Cunha-Vaz, Theodore Smith; Changes in Subretinal Drusenoid Deposits (SDD) During Progression to Geographic Atrophy (GA) and Choroidal Neovascularization (CNV) in Age-Related Macular Degeneration (AMD). Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5151.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

This retrospective study utilized 3 imaging modalities to quantitatively analyze SDD evolution in eyes that progressed from early to late AMD over a 2-year follow-up period. We analyzed the change in SDD area within the fundus, both in subjects who progressed to GA and in those who progressed to CNV, with the goal of better understanding the dynamic spatiotemporal nature of SDD and their role in AMD progression.

 
Methods
 

25 patients with AMD and unilateral CNV were included. The non-CNV eyes (the study eyes) all underwent indocyanine green angiography (ICG), short-wavelength autofluorescence (AF), and near infrared reflectance (NIR) imaging at baseline and at 2-year follow-up. Study eyes were analyzed for SDD and for the development of late AMD—both CNV and geographic atrophy (GA). SDD area measurements were obtained by two graders utilizing ImageJ software and are expressed as a percentage of total fundus area; binary logistic regression and the Wilcoxon nonparametric test were used for statistical analysis.

 
Results
 

8 study eyes developed GA and 17 study eyes developed CNV during the follow-up period. In the eyes that developed CNV, there was a statistically significant decrease in SDD area as seen on AF (P=0.004) and NIR (P=0.027), and the decrease in SDD area approached statistical significance on ICG (P=0.078). By contrast, in the eyes that developed GA, there was no significant change in SDD area as seen on all 3 imaging modalities (ICG: P=0.75, AF: P=0.275, and NIR: P=1).

 
Conclusions
 

SDD undergo dynamic spatiotemporal changes in eyes with AMD. These lesions can be seen in eyes that progress to late AMD, both GA and CNV, but a decrease in SDD area is seen only during progression to CNV, likely as a result of worse ischemia and increased VEGF in CNV subjects. These results suggest that the SDD lesions migrate, are absorbed by surrounding cells, or are no longer visible due to imaging difficulties secondary to changes present in CNV.  

 
All images are from the same subject; A-C at initial imaging, D-F at final follow-up. A&D=ICG, B&E=AF, C&F=NIR
 
All images are from the same subject; A-C at initial imaging, D-F at final follow-up. A&D=ICG, B&E=AF, C&F=NIR

 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×