June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Change in Outer Retinal Layer Thickness in Subjects with Reticular Pseudodrusen
Author Affiliations & Notes
  • Muneeswar Gupta Nittala
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Yan Luo
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Zhihong Hu
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Ruth E Hogg
    Center for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom
  • Rufino Silva
    Ophthalmology Unit, Centro Hospitalare Universitário Coimbra, Coimbra, Portugal
  • Giovanni Staurenghi
    Department of Clinical Science Luigi Sacco' University of Milan, Milan, Italy
  • Usha Chakravarthy
    Center for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom
  • Srinivas R Sadda
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
    Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA
  • Footnotes
    Commercial Relationships Muneeswar Gupta Nittala, None; Yan Luo, None; Zhihong Hu, None; Ruth Hogg, None; Rufino Silva, Alcon, Alimera, Allergan, Bayer, Novartis, THEA (C); Giovanni Staurenghi, None; Usha Chakravarthy, None; Srinivas Sadda, Carl Zeiss Meditec, Optos, Allergan (R), Carl Zeiss Meditec, Optos, Allergan, Genentech (F), Carl Zeiss Meditec, Optos, Allergan, Genentech, Alcon, Novartis, Roche (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5165. doi:https://doi.org/
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      Muneeswar Gupta Nittala, Yan Luo, Zhihong Hu, Ruth E Hogg, Rufino Silva, Giovanni Staurenghi, Usha Chakravarthy, Srinivas R Sadda; Change in Outer Retinal Layer Thickness in Subjects with Reticular Pseudodrusen. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5165. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the thickness of the outer retinal layers in subjects with reticular pseudodrusen.

Methods: Thirty four eyes of 34 subjects with reticular pseudodrusen (RPD) and 39 eyes of 39 subjects with early non-neovascular age-related macular degeneration without RPD were enrolled in this prospective study at three clinical sites (Belfast, Coimbra, Milan). These subjects been fallowed up for one year. Spectral domain optical coherence tomography (SD-OCT) volume scans was collected in 3 clinical sites from Belfast, Coimbra and Milan using Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg Germany). Detailed manual segmentation of outer retinal layers was performed using custom designed and validated grading software 3D OCTOR. Thickness measurements were derived for retina, photoreceptor outer segments, RPE+Drusen complex and Choroid layers in both the study cohorts.

Results: was no significant difference in retinal thickness and photoreceptor outer segments thickness between study groups. There was significant (p=0.004) difference in RPE+Drusen complex layer thickness in RPD subjects (30.6 ± 3.69 (±SD) µm) compared to those without RPD (28.21 ± 2.35 µm). In contrast, the choroid was significantly thinner (p = 0.04) in RPD subjects with a thickness of149.78 ± 33.56 compared with 162.42 ± 36.24 µm in subjects without RPD. Longitudinal analysis, revealed a small but significant (p = 0.04) thinning (25.53 ± 3.71 µm at baseline vs 24.03 ± 4.32 µm at month 12) in RPD subjects, compared to no significant change over time in subjects with no RPD.

Conclusions: The RPE+ Drusen complex layer is significantly thicker and the choroid is significantly thinner in subjects with reticular pseudodrusen. The photoreceptor outer segments appear to thin over time in eyes with RPD.

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