June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Surgical strabismus in Down syndrome patients
Author Affiliations & Notes
  • Jeffrey Hollander
    Ophthalmology, Boston Children's Hospital, Boston, MA
  • Luai Eldweik
    Ophthalmology, Boston Children's Hospital, Boston, MA
  • Danielle Ledoux
    Ophthalmology, Boston Children's Hospital, Boston, MA
  • Footnotes
    Commercial Relationships Jeffrey Hollander, None; Luai Eldweik, None; Danielle Ledoux, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5225. doi:
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      Jeffrey Hollander, Luai Eldweik, Danielle Ledoux; Surgical strabismus in Down syndrome patients. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5225.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: There is an increased incidence of acquired strabismus in the Down syndrome population, more commonly resulting in esotropia than other deviations. We performed a retrospective chart review of the Down syndrome population with esotropia who had strabismus surgery to better understand the types of esotropia seen and the surgical outcomes.

Methods: We performed a seven year (2007-2014) retrospective chart review of all patients with a diagnosis of Down syndrome who had surgery for strabismus at a single, tertiary care center. Data including indications for surgery, preoperative and postoperative sensorimotor exam, presence of anomalous head posture, and type of surgery were recorded. Postoperative exam was at least one month after surgery. Surgical success was defined using three criteria: i) orthotropia to an esotropia of less than, or equal to 8 prism diopters in primary position, ii) improvement of anomalous head posture, and iii) no further indication for surgery.

Results: 16 patients were identified who had Down syndrome and were surgically treated for esotropia. Of these 1 was excluded due to follow-up of only two weeks. Preoperative findings of the remaining 15 patients included 8 (53%) with an A-pattern, 1 (7%) with a V-pattern, 1 (7%) with a head tilt dependent esotropia, 2 (13%) who had no assessment of pattern, and 3 (20%) with no pattern of esotropia. Anomalous head postures were appreciated in 5 (33%) patients preoperatively, resolved in 4 patients postoperatively, and persisted in 1. In addition, 2 other patients had anomalous head postures not appreciated preoperatively. Of the 8 patients with an A-pattern esotropia, 4 were treated with only a bilateral medial rectus recession, 3 (75%) of who required a second surgery. Ultimately, 7 of the 8 patients achieved successful surgical outcomes. Overall surgical success in this study was 87% (13/15). 2 patients were deemed surgical failures due to persistence of anomalous head posture and esotropia.

Conclusions: Surgical success was achieved in 87% of patients with Down syndrome and esotropia. We identified an increased incidence of A-pattern strabismus in the Down syndrome population, a finding not previously noted. All 3 patients who required reoperation had A-patterns that were not addressed at the time of surgery. Ultimately, 88% of patients with A-pattern strabismus achieved successful surgical outcomes. Recognition of patterns preoperatively may help guide the surgical plan.


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