June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Comparison of the manually delineated Foveal Avascular Zone on Traditional Fluorescein Angiography and Doppler Optical Coherence Tomography Images acquired using a 1060nm Swept-Source Speckle-Variance Doppler-OCT Angiography Prototype
Author Affiliations & Notes
  • Christoph Mitsch
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Jan Lammer
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Laurin Ginner
    Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Daniel Fechtig
    Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Cedric Blatter
    Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Rainer A Leitgeb
    Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Christoph Mitsch, None; Jan Lammer, None; Laurin Ginner, None; Daniel Fechtig, None; Cedric Blatter, None; Rainer Leitgeb, None; Ursula Schmidt-Erfurth, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5271. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Christoph Mitsch, Jan Lammer, Laurin Ginner, Daniel Fechtig, Cedric Blatter, Rainer A Leitgeb, Ursula Schmidt-Erfurth; Comparison of the manually delineated Foveal Avascular Zone on Traditional Fluorescein Angiography and Doppler Optical Coherence Tomography Images acquired using a 1060nm Swept-Source Speckle-Variance Doppler-OCT Angiography Prototype. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5271. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Doppler-optical coherence angiography (DOCT-A) represents a non-invasive alternative to traditional, dye-based fluorescein angiography (FA). Due to the considerable difference of the image acquisition and computation techniques of both modalities, the comparability of the results needs to be evaluated.

Methods: On a single-day visit, patients underwent both FA and DOCT-A examinations. Early phase FA images were exported and en-face projections of of the DOCT-A image stacks were generated. The resulting dataset was duplicated and masked. Two graders delineated the foveal avascular zone (FAZ) on every image of each patient and modality two times. The resulting FAZ area values were compared by calculating the Spearman Product-Moment Correlation Coefficient to illustrate inter- and intra-grader reproducibility in both modalities and the intra-modality reproducibility.

Results: 22 eyes of 18 patients with different retinal pathologies were imaged. The FAZ areas (in square degrees) delineated in DOCT-A images measured 2.97±1.98 (range 0.68-9.24) in grader 1 and 3.69±2.62 (range 0.99-11.89) in grader 2. On FA, the areas measured 3.51±2.32 (range 0.83-10.33) in grader 1 and 5.15±3.89 (range 1.58-17.47) in grader 2, respectively. The intra-grader FAZ delineation correlation coefficients in DOCT-A and FA were 0.88 and 0.99 in grader 1 and 0.8 and 0.83 in grader 2. The resulting inter-grader DOCT-A and FA correlation coefficients were 0.75 and -0.25, respectively. Inter-modality correlation coefficients were 0.36 in grader 1, 0.1 in grader 2 and 0.29 for the means.

Conclusions: The FAZ area delineated on DOCT-A images showed strong inter-grader correlation, higher than in FA images, which was only weak. Inter-modality correlation was weak in one grader and in the grader means and very weak in the other grader. Although these results may reveal a wide range of interpretability differences for both modalities, the strong inter-grader correlation in DOCT-A FAZ delineation detected in our data is promising. The weak intra-modality comparability needs to be interpreted accounting for the elemental differences of both image acquisition techniques and their resulting individual sources of quality- and interpretability cutbacks.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×