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Jost B Jonas, Leonard Holbach, Songhomitra Panda-Jonas; Choroidal Cross Section Area and Choroidal Volume and Axial Length. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5286. doi: https://doi.org/.
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To examine whether the choroidal cross sectional area and estimated choroidal volume are associated with a longer axial length in human eyes.
Histologic anterior-posterior sections running through the pupil and the optic nerve head were examined. Using a light microscope, we measured thickness of the choroid at the limbus, ora serrata, equator, midpoint between equator and posterior pole (MPEPP), peripapillary region and posterior pole. The axial length and the horizontal and vertical diameters of the globe were measured with a ruler or caliper. We calculated the choroidal volume as inner scleral surface area times choroidal thickness.
The histomorphometric study included 53 human globes (53 subjects; mean age: 60.7 ± 19.4 years) enucleated due to malignant choroidal melanoma or due to secondary angle-closure glaucoma. Mean axial length was 27.1 ± 4.0 mm (median: 26.0 mm; range: 21-39 mm). Choroidal thickness measurements decreased with increasing axial length for values taken at the midpoint between posterior pole and equator (P=0.08;r=-0.24), at the optic nerve head border (P=0.02;r=-0.33) and at the posterior pole (P=0.008;r=-0.36;beta:-0.36). Choroidal thickness measured at the equator (P=0.58) and at the ora serrata (P=0.66) were not associated with axial length. Neither choroidal cross section area measured from the ora serrata to the posterior pole (P=0.58) nor choroidal volume measured from the ora serrata to the posterior pole (P=0.35) were significantly associated with axial length.
Choroidal thickness in the posterior quarter of the globe decreased with increasing axial length, most marked at the posterior pole. Total choroidal volume was not associated with axial length, pointing against a choroidal volume enlargement to play a role in, or to be associated with, the process of myopic axial elongation.
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