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Livio Giulio Marco Franco, Teresio Avitabile, Michele Reibaldi, Antonio Longo, Vincenza Bonfiglio, Seby Flavio Gulisano, Pietro Valerio Foti, marco ragusa, Rosario Caltabiano, Andrea Russo; Diffusion-Weighted Magnetic Resonance Imaging And Ultrasound Evaluation Of Choroidal Melanomas After Proton Beam Therapy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5344.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the ultrasound and magnetic resonance imaging parameters of ocular melanoma and to assess their variation after proton-beam therapy.
Fifteen choroidal melanoma patients treated with proton-beam therapy were enrolled in the study. All patients underwent ophthalmologic evaluations, ultrasound, conventional magnetic resonance (MR) imaging and diffusion-weighted MR imaging before the start of therapy and 3 and 6 months after therapy. Basal diameters, thickness, internal reflectivity, tumor volumes and apparent diffusion coefficient (ADC) values of ocular melanomas were measured at each examination. Correlations between internal reflectivity and ADC were investigated.
No significant changes were seen in tumor diameters and tumor height as assessed by B-scan and A-scan respectively. Significant increase in mean tumor internal reflectivity was detected at 6 months (baseline: 35 % ± 11; 6 months: 48 % ± 8, Tukey-Kramer p=0.005). By MRI, compared to baseline (mean 547 ± 262 mm3), a significant reduction in volume was seen at 6 months (Tukey-Kramer p= 0.045) (mean volume 339 ± 170 mm3, mean reduction 38%). A significant increase in ADC (baseline 1002 ± 109 mm2/sec) was detected both at 3 and 6 months after proton-therapy (respectively 1454 ± 90 and 1833±261, mm2/sec, both p<0.001).
By MRI, in particular by ADC assessment, it is possible to detect early variations in melanoma treated by proton beam therapy. This examination could be used together with ultrasound in the follow-up of this treatment.
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