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Amir Mohsenin, Vivek A. Rudrapatna, George J Harocopos, Sander R Dubovy, J William Harbour; Diffuse Intraocular Proliferation of uveal melanoma following radiotherapy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5345.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the presentation and management of diffuse intraocular proliferation of uveal melanoma following radiotherapy
A retrospective chart review was conducted identifying patients with uveal melanoma treated with radiotherapy who later developed vitreous and retinal invasion by melanoma cells.
5 patients were identified. All patients had a collar-button tumor configuration. 1 patient had a biopsy performed at time of radiotherapy. 1 patient was managed with vitrectomy alone. 2 patients that were initially treated with vitrectomy and intravitreal methotrexate required enucleation. Enucleated specimens demonstrated retinal and vitreous invasion by melanoma cells.
Intraocular proliferation of uveal melanoma is a rare and challenging sequela after radiotherapy that may warrant aggressive intervention.
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