Diffuse Intraocular Proliferation of uveal melanoma following radiotherapy

Abstract

 

Purpose

 

To describe the presentation and management of diffuse intraocular proliferation of uveal melanoma following radiotherapy

 

Methods

 

A retrospective chart review was conducted identifying patients with uveal melanoma treated with radiotherapy who later developed vitreous and retinal invasion by melanoma cells.

 

Results

 

5 patients were identified. All patients had a collar-button tumor configuration. 1 patient had a biopsy performed at time of radiotherapy. 1 patient was managed with vitrectomy alone. 2 patients that were initially treated with vitrectomy and intravitreal methotrexate required enucleation. Enucleated specimens demonstrated retinal and vitreous invasion by melanoma cells.

 

Conclusions

 

Intraocular proliferation of uveal melanoma is a rare and challenging sequela after radiotherapy that may warrant aggressive intervention.