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Nassim S Calixto, Maria Valeria C Pereira Silva, Sebastiao Cronemberger, Eduardo Gutemberg Milhomens, Adalmir Morterá Dantas; Peters’ anomaly: A Clinical Study of 36 Patients. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5640.
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To describe the clinical findings of 36 patients with Peters’ anomaly (PA).
We analyzed the medical records of 36 patients with Peters’ anomaly from 1968 to 2014. We included only those records that presented complete biomicroscopic findings. We assessed demographic data, first degree relatives in the family history, biomicroscopy, intraocular pressure, horizontal corneal diameter (HCD) and axial length. Statistical analysis was descriptive.
<br /> Peters’ anomaly is a rare form of ocular anterior segment dysgenesis related to abnormal crest cells migration.<br /> We included 36 patients, 22 males and 14 females. Fourteen were white, 14 mulatto, 3 black and in 5 cases race wasn’t available. Peters’ anomaly is congenital but, in spite of this, the patients’ age at the first examination in our sample ranged from 2 days to 122 months. Peters` anomaly was bilateral in 23 (64%) patients and unilateral in 13 (36%). Three patients had parents that were cousins. The most important biomicroscopic findings were: 1. Corneal opacities with or without posterior ulcer; 2. Annular or partial anterior synechiae; 3. Narrow anterior chamber depth; 4. Iris’ changes and lens opacities; 5. The structural corneal changes invalidate the true IOP values. Despite of this, the approximate IOP values at the initial examination were 11.11±8.5mmHg in the right eye (RE) and 10.76±8.05 mmHg in the left eye (LE); 6. The initial HCD average was 11.93±1.62 mm in RE and 12.22±1.9 mm in LE; 7. The axial length average was 22.00±3.12 mm in RE and 21.52±3.67mm in LE. Some eyes included in this sample had already abnormal axial length at the first examination.
Peters’ anomaly predominantly affects both eyes. The structural corneal changes render the IOP measurements less reliable. Narrow anterior chamber and iris’ changes were found in the great majority of eyes with PA. The average initial HCD and axial length were within the normal range but the standard deviation was high.
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