June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Photobiomodulation (phototherapy) of retinal tissue in Stargardt disease
Author Affiliations & Notes
  • Sergio Zaccaria Scalinci
    Ophthalmology, University of Bologna SOrsola Malpighi, Bologna, Italy
    DIMEC, S.Orsola-Malpighi Hospital, Bologna, Italy
  • Francesco Milone
    Università, Verona, Italy
  • Mariangela Magnifico
    Santa Lucia private hospital, Bologna, Italy
  • Caterina Berti
    Santa Lucia private hospital, Bologna, Italy
  • Paolo G. Limoli
    Centro studi ipovisione, Milano, Italy
  • Enzo M Vingolo
    UOC Ophthal Hosp ""A. Fiorini"" Terracina, Roma, Italy
  • Daniela Domanico
    Univ La Sapienza Osp. ""S. M. Goretti"" LT, Roma, Italy
  • Lucia Scorolli
    Santa Lucia private hospital, Bologna, Italy
    S.Orsola-Malpighi Hospital, Bologna, Italy
  • Footnotes
    Commercial Relationships Sergio Zaccaria Scalinci, None; Francesco Milone, None; Mariangela Magnifico, None; Caterina Berti, None; Paolo Limoli, None; Enzo Vingolo, None; Daniela Domanico, None; Lucia Scorolli, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5668. doi:
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      Sergio Zaccaria Scalinci, Francesco Milone, Mariangela Magnifico, Caterina Berti, Paolo G. Limoli, Enzo M Vingolo, Daniela Domanico, Lucia Scorolli; Photobiomodulation (phototherapy) of retinal tissue in Stargardt disease. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5668.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To analyse functional data in 36 patients affected by Stargardt Disease with mutations in the ABCA4 gene after photobiomodulation with mnemosline (Model MNEMOSLINE, made by KALOS, EC CERTIFICATE N°1419/MDD, TELEA ELECTR. ENG. SRL. Sandrigo (VI)- ITALY) in order of improving visual functions.

Methods: Polycentric prospective study (Bologna, Milano, Rome- ITALY) in genetic analised patients.<br /> 36 patients, average age 20.2+1.3 sd (12 enrolled in Bologne, 12 in Milan and 12 in Rome) with Fishman I Stargardt disease classification ( Arch. Ophthal. 1999). We evaluated best corrected visual acuity (BCVA), reading speed (w/min), microperimetry (MP-1), pattern electroretinography (PERG). Exams were repeated at start up time, at 1,2,3 months. Mnemosline was used for 10 minutes, 2 times a day, 5 days per week for 3 months.<br /> Red LED 650 nm pulsed light has the better penetrative capacity in tissue without termal increase, activating chromophore (cytochrome c oxidase) response, improving ATP (Amat et al, 2006).

Results: <br /> BCVA ranged between 0.6-1.0 logMAR, using ETDRS charts. ETDRS letters went from 34 to 37,67. From 100% to 113.3% percentage variation of PERG ( Anova statistic) Retinal sensibility (MP-1) mesured in dB growed from 10.68 to 12.29. W/min growed from 65.67 to 84.

Conclusions: LED pulsed light 650 nm may have beneficial effects in Stargardt disease upregulating mitochondrial cytochrome c oxidase in the retinal tissue. More extensive trials are request.


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